替加环素治疗多重耐药菌所致重症肺炎的效果及对氧代谢状态的影响  

Effect of Tigecycline in the treatment of severe pneumonia caused by multidrug resistant bacteria and its influence on oxygen metabolism state

作　　者：张妍[1] 苏晓蕾[1] 赵睿[1] 韩世权[1] 朱虹[1] 房开宇[1] 陈晓园[1] ZHANG Yan;SU Xiaolei;ZHAO Rui;HAN Shiquan;ZHU Hong;FANG Kaiyu;CHEN Xiaoyuan(Ward Two,Intensive Care Unit,Dalian Municipal Central Hospital,Liaoning Province,Dalian 116033,China)

机构地区：[1]辽宁省大连市中心医院重症监护病房第二病房,辽宁大连116033

出　　处：《中国医药导报》2018年第27期106-109,共4页China Medical Herald

摘　　要：目的探讨替加环素治疗多重耐药菌所致重症肺炎的效果及对氧代谢状态的影响。方法选择2016年10月～2017年11月于大连市中心医院确诊的92例多重耐药菌所致重症肺炎患者,依据治疗方式的不同将其分为对照组和研究组,每组各46例。对照组给予头孢哌酮舒巴坦静滴治疗,研究组在对照组治疗的基础上给予替加环素静脉滴注。两组均治疗3 d。观察比较两组治疗后的效果,检测两组患者治疗前1 d和治疗后3 d的氧代谢状态(氧供与氧耗状态),比较两组治疗中的不良反应发生率。结果治疗后,研究组的疗效优于对照组,差异有统计学意义(P<0.05);治疗后3 d,两组氧供(DO_2)及氧供指数(DO_2I)、氧耗(VO_2)及氧耗指数(VO_2I)、动脉血氧分压(PaO_2)及动脉血氧饱合度(SaO_2)均明显高于治疗前,差异有统计学意义(P<0.05),且研究组治疗后3 d的DO_2、DO_2I、VO_2、VO_2I、PaO_2及SaO_2检测值均明显高于对照组,差异有统计学意义(P<0.05);两组治疗过程中腹泻、恶心、呕吐及皮疹等不良反应发生率比较差异无统计学意义(P>0.05)。结论替加环素治疗多重耐药菌所致重症肺炎患者的效果较好,有助于改善患者的氧代谢状态,且未明显增加不良反应,值得推广应用。Objective To investigate the effect of Tigecycline in the treatment of severe pneumonia caused by multidrug resistant bacteria and its influence on oxygen metabolism state. Methods From October 2016 to November 2017, 92 patients diagnosed as severe pneumonia caused by multidrug resistant bacteria in Dalian Municipal Central Hospital were selected and divided into control group and study group according to the different treatment methods, with 46 cases in each group. The control group was treated with Cefoperazone-Sulbactam by intravenous drip, the study group was treated with Tigecycline by intravenous drip on the basis of treatment of control group. The treatment of two groups lasted for 3 d. The curative effects of the two groups were observed and compared after treatment, the oxygen metabolism state（oxygen supply and oxygen consumption state） of two groups were detected 1 d before treatment and 3 d after treatment, and the adverse reactions rates of the two groups during the treatment were compared. Results After treatment, the curative effect of study group was significantly better than that of control group, the difference was statistically significant（P〈0.05）. The oxygen supply（DO2） and oxygen supply index（DO2 I）, oxygen consumption（VO2）and oxygen consumption index（VO2 I）, arterial oxygen pressure（PaO2） and arterial oxygen saturation（SaO2） of the two groups 3 d after treatment were higher than those before treatment, the differences were statistically significant（P〈0.05）, and the detection values of DO2, DO2 I, VO2, VO2 I, PaO2 and SaO2 of study group 3 d after treatment were significantly higher than those of control group, the differences were statistically significant（ P〈0.05）. There were no significant differences in the rates of adverse reactions including diarrhea, nausea, vomiting and rash during treatment between the two groups（ P〈0.05）. Conclusion Tigecycline is effective in the treatment of patients with severe pneumonia caused by multidrug resis

关 键 词：替加环素 头孢哌酮舒巴坦 多重耐药菌 重症肺炎 氧代谢状态 

分 类 号：R978.14[医药卫生—药品]