胃复春治疗幽门螺杆菌阳性慢性萎缩性胃炎的疗效及对胃液pH、胃蛋白酶原的影响  

Clinical Efficacy of Weifuchun Pill on Helicobacter Pylori Positive Chronic Atrophic Gastritis and Effects on p H and Pepsinogen in Gastric Juice

作　　者：卢岱魏[1] 陈昱倩[1] 刘沈林[1] 王东旭[1] Lu Daiwei;Chen Yuqian;Liu Shenlin;Wang Dongxu(Department of Geriatrics,Affiliated Hospital of Integrated Traditional Chinese and Western Medicine of Nanjing University of Chinese Medicine,Nanjing 210014,China)

机构地区：[1]南京中医药大学附属南京市中西医结合医院老年病科,南京210014

出　　处：《世界中医药》2018年第9期2182-2185,共4页World Chinese Medicine

基　　金：南京市卫生和计划生育委员会基金项目(2015sc515007)

摘　　要：目的:探究胃复春治疗幽门螺杆菌阳性慢性萎缩性胃炎的疗效及对胃液p H、胃蛋白酶原的影响。方法:选取2014年8月至2016年8月在南京中医药大学附属南京市中西医结合医院老年病科和脾胃病科就诊的幽门螺杆菌阳性慢性萎缩性胃炎患者200例,随机分为对照组和观察组,每组100例。2组患者基础抗幽门螺杆菌治疗均采用标准三联方案,观察组在此基础上给予胃复春片治疗,连续治疗4周。治疗后比较2组胃液p H、幽门螺杆菌阳性率、胃蛋白酶原及疗效。结果:与治疗前比较,治疗后2组胃内p H值均显著升高,观察组高于对照组(P<0.05);与治疗前比较,2组幽门螺杆菌阳性率均显著下降,且观察组低于对照组(P<0.05);与治疗前比较,治疗后2组胃蛋白酶1、2水平均显著升高,且观察组高于对照组(P<0.05);治疗后观察组总有效率为93.83%,较对照组的79.07%显著升高(P<0.05)。结论:胃复春对幽门螺杆菌阳性慢性萎缩性胃炎患者疗效显著,同时提高胃液p H和胃蛋白酶原水平。Objective： To explore the clinical efficacy of Weifuchun Pill on Helicobacter pylori （H.pylori） positive chronic atrophic gastritis and effects on pH and pepsinogen in gastric juice. Methods： A total of 200 patients with H.pylori positive chronic atrophic gastritis treated in the Department of Geriatrics and the Department of Spleen and Stomach Diseases of Affiliated Hospital of Integrated Traditional Chinese and Western Medicine of Nanjing University of Chinese Medicine from August 2014 to August 2016 were selected and randomly divided into control group and study group,with 100 cases in each group.In both groups,the basic anti-Helicobacter pylori treatment was performed by standard triple therapy,and the observation group was given Weifuchun tablets on the basis of this treatment for 4 weeks.After treatment,the gastric juice pH,Helicobacter pylori positive rate,pepsinogen and curative efficacy were compared between 2 groups. Results： Compared with before treatment,the level of pH in stomach of both groups was increased significantly after the treatment,and the study group increased more than the control group （ P 〈0.01）.Compared with before treatment,the positive rate of Helicobacter pylori in both groups was decreased significantly,and the study group decreased more than the control group （ P 〈0.01）.The levels of pepsin 1 and 2 in the 2 groups were significantly increased,and the study group increased more than that of the control group （ P 〈0.01）.After treatment,the total effective rate of the study group was 93.83%,which was significantly higher than that of the control group （79.07%） （ P 〈0.01）. Conclusion： Weifuchun Pills has significant clinical effects on Helicobacter pylori positive chronic atrophic gastritis,and can improve gastric juice pH and pepsinogen levels.

关 键 词：胃复春 幽门螺杆菌 慢性萎缩性胃炎 胃蛋白酶 

分 类 号：R289.5[医药卫生—方剂学] R573[医药卫生—中药学]