益气清热解毒化瘀法治疗溃疡性结肠炎的疗效及对高凝状态及炎性反应因子的影响  

Efficacy of Yiqi Qingre Jiedu Huayu Method in the Treatment of Ulcerative Colitis and Effects on the High Coagulation State and Inflammatory Factors

作　　者：赵锁林[1] 韩伟 刘甜 张阳阳 王静静 Zhao Suolin;Han Wei;Liu Tian;Zhang Yangyang;Wang Jingjing(Baoji Maternal and Child Health Hospital,Baoji 721000,China;The School of Life Sciences,Northwest University,Xi′an 710069,China)

机构地区：[1]宝鸡市妇幼保健院,宝鸡721000 [2]西北大学生命科学学院,西安710069

出　　处：《世界中医药》2018年第9期2189-2192,共4页World Chinese Medicine

基　　金：陕西省卫生科研基金项目(2014D254)

摘　　要：目的:研究益气清热解毒化瘀法治疗溃疡性结肠炎的临床疗效及对高凝状态、炎性反应因子的影响。方法:选取2015年6月到2017年8月宝鸡市妇幼保健院收治的溃疡性结肠炎患者130例,随机分为对照组和观察组,每组65例,对照组给予常规治疗,观察组加用益气清热解毒化瘀法治疗,2组均治疗2个月,观察2组患者的临床疗效及不良反应发生情况,比较治疗前后2组患者高凝状态指标、炎性反应因子指标、临床症状积分指标水平。结果:观察组总有效率为93.85%(61/65),高于对照组的80.00%(52/65)(P<0.05)。2组患者治疗期间均未发生严重的不良反应。2组患者治疗2个月后肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)以及超敏C反应蛋白(hs-CRP)、血小板计数(Plt)、D-二聚体、纤维蛋白原(FIB)均明显降低,且观察组低于对照组(P<0.05)。2组患者治疗2个月后临床症状积分和肠镜检查积分均明显降低,且观察组低于对照组(P<0.05)。结论:益气清热解毒化瘀法治疗溃疡性结肠炎疗效确切,能有效改善高凝状态,降低炎性因子水平,并可改善症状评分,安全性较好,值得进一步推广。Objective： To study the clinical effect of Yiqi Qingre Jiedu Huayu Method in the treatment of ulcerative colitis and effects on the high coagulation state and inflammatory factors. Methods： A total of 130 patients with ulcerative colitis treated in Baoji Maternal and Child Health Hospital from June 2015 to August 2017 were selected and randomly divided into control group and observation group,with 65 cases in each group.The control group was given conventional treatment,while the observation group was treated with Yiqi Qingre Jiedu Huayu Method based on the same treatment of control group.Both groups were treated for 2 months to observe the clinical efficiency and adverse reactions and to compare the indexes of high coagulation state,inflammatory factors,clinical symptom scores before and after treatment. Results： The total effective rate of observation group was 93.85% （61/65）,which was higher than the 80.00% （52/65） of the control group （ P 〈0.05）.No serious adverse reactions occurred during the treatment of both groups.After 2 months′ treatment,the tumor necrosis factor-α （TNF-α）,interleukin-6 （IL-6）,high sensitive C reactive protein （hs-CRP）,Platelet （Plt）,D-two polymer,fibrinogen （FIB） of both groups were significantly reduced,and the observation group were lower than that in the control group （ P 〈0.05）.After 2 months′ treatment,the clinical symptom scores and colonoscopy integral of both groups were significantly reduced,and the scores of observation group reduced more than that in the control group （ P 〈0.05）. Conclusion： Yiqi Qingre Jiedu Huayu Method in the treatment of ulcerative colitis has significant effects,which can effectively improve hypercoagulability,reduce the level of inflammatory factors,improve the symptom scores,and it is safe and worthy of further promotion.

关 键 词：益气清热解毒化瘀法 溃疡性结肠炎 高凝状态 炎性因子 疗效 

分 类 号：R285.6[医药卫生—中药学] R242[医药卫生—中医学]