首荟通便胶囊对慢传输型便秘模型大鼠肠道推进率和结肠黏液分泌的影响  

Effects of Shouhui Tongbian Capsule on Intestine Pushing Rate and Colonic Mucus Secretion in Rats with Slow Transit Constipation

作　　者：李冰冰 谭玉军 姚景春 程国良 黄志艳 张贵民 Li Bingbing;Tan Yujun;Yao Jingchun;Cheng Guoliang;Huang Zhiyan;Zhang Guimin(National Chiral Pharmaceutical Engineering Technology Research Center,Linyi 276000,China)

机构地区：[1]国家手性制药工程技术研究中心,临沂276000

出　　处：《世界中医药》2018年第9期2268-2271,共4页World Chinese Medicine

基　　金：上海市教育委员会E-研究院建设计划项目(03008)

摘　　要：目的:观察首荟通便胶囊对慢传输型便秘模型动物肠道推进率和结肠黏液分泌的影响,探讨首荟通便胶囊对慢传输型便秘的疗效及相关机制。方法:灌胃给予复方地芬诺酯片并限水导致大鼠慢传输型便秘模型,模型大鼠随机分为模型组、首荟通便胶囊高、首荟通便胶囊中、首荟通便胶囊低剂量组、芪蓉润肠口服液组。观察首荟通便胶囊对复方地芬诺酯(DC)便秘模型大鼠小肠碳墨推进率、首次黑便排出时间和12 h排便颗粒数的影响。结扎分离取出的盲结肠段随即固定,制作石蜡切片,AB-PAS染色,供组织学观察。结果:首荟通便胶囊中、高剂量组可明显缩短大鼠首次排便时间(P<0.05),增加12 h排便颗粒数(P<0.05),并且能增加小肠碳墨推进率(P<0.05)。首荟通便胶囊中、高剂量组大鼠结肠黏膜黏液细胞数明显增多,与模型组比较差异有统计学意义(P<0.05)。结论:首荟通便胶囊能够通过提高肠道动力,增加结肠黏液的分泌,有效改善便秘症状,提高患者的生命质量。Objective： To investigate the effects of Shouhui Tongbian Capsule on intestine pushing rate and colonic mucus secretion in slow transit constipation model animals,and to explore the correlating mechanism of Shouhui Tongbian Capsule on slow transit constipation. Methods： The rat model of slow transit constipation was established by intragastric administration with compound diphenoxylate tablet and water restriction.The model rats were randomly divided into control group,Shouhui Tongbian Capsule high,middle,low dose groups and Qirong Runchang Oral Liquid.The pushing rate of intestine,the time of first black stool discharge and the number of fecal particles in 12 h in compound difenolate （DC） constipation model rats were observed.Cecocolon sections removed by ligation were fixed and paraffin sections were prepared and stained with AB-PAS for histological observation. Results： Compared with the control group,Shouhui Tongbian Capsule significantly reduced the time of first black stool discharge,increased the intestine pushing rate （ P 〈0.05）.Meanwhile,the black stool points in 12 h increased （ P 〈0.05） in the constipation model rats which were induced by compound diphenoxylate tablets.The number of mucous cells in the colonic mucosa of rats in medium and high dose Shouhui Tongbian Capsule groups increased significantly,and compared with the model group,the difference was statistically significant （ P 〈0.05）. Conclusion： Shouhui Tongbian Capsule can improve intestinal motility,increasing mucus secretion of colon to effectively improve constipation symptoms and improve the quality of life of patients.

关 键 词：首荟通便胶囊 慢传输型便秘 推进率 结肠黏液分泌 

分 类 号：R932[医药卫生—生药学] R574.4[医药卫生—药学]