Direct Synthesis of Structurally Divergent Indole Alkaloids from Simple Chemicals  

作　　者：Tao Shen Bencong Zhu Fengguirong Lin Jun Pan Jialiang Wei Xiao Luo Jianzhong Liu Ning Jiao 

机构地区：[1]State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Rd. 38, Beijing 100191, China [2]State Key Laboratory of Organometallic Chemistry, Chinese Academy of Sciences, Shanghai 200062, China

出　　处：《Chinese Journal of Chemistry》2018年第9期815-818,共4页中国化学（英文版）

摘　　要：A direct and structurally divergent synthesis of indole alkaloids from very simple 2-vinylanilines, alkynes and TBN via a novel substrate flag- mentation/cycloaddition strategy has been developed, which provides an efficient noble-metal-free approach to access a library of highly valuable indole derivatives of tryptamines and tryptamine-related oximes, lactams, and lactones, as well as β-carbolines, spiroindolines, and hexa-hydropyrrolo[2,3-b]- indoles.A direct and structurally divergent synthesis of indole alkaloids from very simple 2-vinylanilines, alkynes and TBN via a novel substrate flag- mentation/cycloaddition strategy has been developed, which provides an efficient noble-metal-free approach to access a library of highly valuable indole derivatives of tryptamines and tryptamine-related oximes, lactams, and lactones, as well as β-carbolines, spiroindolines, and hexa-hydropyrrolo[2,3-b]- indoles.

关 键 词：C--C bond cleavage molecular diversity indole alkaloids trypthamines RADICALS 

分 类 号：O626.13[理学—有机化学] TS727[理学—化学]