2013-2017年河北省承德市健康人群麻疹IgG抗体水平监测分析  

Analysis of measles antibody level in healthy population during 2013 – 2017 in Chengde City of Hebei

作　　者：李琦[1] 赵国良[1] 高桂珍[1] 关志国[1] 牛璞生[1] LI Qi;ZHAO Guoliang;GAO Guizhen;GUAN Zhiguo;NIU Pusheng(Chengde Center for Disease Control and Prevention,Hebei 067000,China)

机构地区：[1]承德市疾病预防控制中心,河北067000

出　　处：《医学动物防制》2018年第10期1011-1013,共3页Journal of Medical Pest Control

基　　金：承德市科学技术研究与发展计划项目(20132081)

摘　　要：目的了解承德市健康人群麻疹血清抗体水平,及时发现高危人群,为制定免疫策略提供科学依据。方法按照分层随机抽样的原则,将健康人群按年龄分为7个年龄组,每组随机抽取不少于15人做为调查对象。应用酶联免疫吸附试验(ELISA)检测麻疹IgG抗体;数据采用SPSS 23.0处理,用描述流行病学方法进行分析。结果共采集血清标本579份,麻疹Ig G抗体阳性率92.06%。不同性别麻疹Ig G抗体阳性率差异无统计学意义(χ2=0.03,P>0.05);不同年龄组间麻疹IgG抗体水平差异有统计学意义(χ2=91.80,P<0.05),其中<1岁和20~岁组麻疹IgG抗体阳性率较低,分别为63.93%和89.83%,3~和5~岁组最高,均达到了100.00%。有麻疹类疫苗免疫史的人群麻疹IgG抗体阳性率高于无麻疹类疫苗免疫史人群,且差异有统计学意义(χ2=18.36,P<0.05)。结论健康人群血清中的麻疹IgG抗体处于较高水平,对麻疹的发生和感染具有较高的免疫力。Objective To understand the measles serum antibody level in healthy population in Chengde City, detect high-risk group, and provide scientific basis for setting up immunization strategies. Methods According to the principle of cluster stratification sampling, the healthy population was divided into 7 different age groups, and each group contained no less than 15 people as the object of investigation. The measles IgG antibody was detected with enzyme-hnked immunosorbent assay （ELISA）. The data obtained were processed using SPSS 23.0 and analyzed by descriptive epidemiological methods. Results A total of 579 blood samples were tested, of which 92.06% were measles IgG positive. The differences of measles IgG antibody positive rate with different gender were not statistically significant （X2 = 0. 03, P〉0. 05）. The differences of measles IgG antibody levels of different age groups were statistically significant （X^2 =91.80, P=0.00）. Measles IgG antibody positive rate was lower in the age groups of those 〈1 years old and ≥20 years old, the rate of which being 63.93% and 89.83% respectively. The rate in the groups of 3 years old and 5 years old was the highest, reaching 100.00%. Measles IgG antibody positive rate in the group with measles vaccine immunization was higher than that in the group without measles vaccine immunization, and the difference was statistically significant（X^2 = 18. 36, P= 0.00）. Conclusion The measles IgG antibody in the serum of healthy people is at a high level and has high immunity to the occurrence and infection of measles.

关 键 词：麻疹 健康人群 抗体水平 

分 类 号：R511.1[医药卫生—内科学]