未服用抗精神病药物的精神分裂症患者血清干扰素-γ和肿瘤坏死因子-α的水平  

Study on the levels of INF- γ and TNF- α in serum of schizophrenic patients without antipsychotics

作　　者：孙志刚[1] 李素水[1] 宋丽华[1] 薛曼[1] 王斌[1] 郭年春[1] Sun Zhigang;Li Sushui;Song Lihua;Xue Man;Wang Bin;Guo Nianchun The Fifth(Department of Psychiatry,the Eighth Hospital of Shijiazhuang,Shijiazhuang 050081,China)

机构地区：[1]石家庄市第八医院精神五科,050081

出　　处：《神经疾病与精神卫生》2018年第7期471-474,共4页Journal of Neuroscience and Mental Health

基　　金：河北省高层次人才资助项目（A2016002087）;河北省科学技术研究发展计划项目（152777223）;石家庄市科学技术研究与发展指导计划项目（171462273）

摘　　要：目的探讨未服用抗精神病药物的精神分裂症患者血清干扰素-γ（INF-γ）和肿瘤坏死因子-α（TNF—α）水平及与症状之间的相关性。方法选取2015年3月-2017年3月在石家庄市第八医院精神科住院的精神分裂症患者38例为研究对象，以我院的健康医护人员30例作为对照组。采用酶联免疫吸附试验检测血清INF-γ和TNF-α浓度，应用阳性与阴性症状量表（PANSS）评定症状的严重性。结果研究组血清IFN-γ和TNF—Q浓度分别为（288．36-4-97．84）pg／ml、（8．59±3．35）pg／ml，显著高于对照组的（225．81zt：76．95）pg／ml、（5．93±2．96）pg／ml（t=2．869、3．420，P均〈0．05）；血清IFN-γ和TNF-α水平与PANSS总分呈正相关，主要与阴性症状相关（P〈O．05）。结论精神分裂症发病后的早期阶段机体存在炎性活化状态，炎性反应过程可能影响急性期的阴性症状。Objective To investigate the levels of interferon- γ （INF- γand tumor necrosis factor- α （TNF- α ） in serum of schizophrenic patients without antipsychotics and the correlation between these levels and symptoms. Methods Totals of 38 cases of schizophrenia patients admitted to psychiatric department of the eighth Hospital of Shijiazhuang were selected as subjects from March 2015 to March 2017. Meanwhile, 30 health care workers of the eighth Hospital of Shijiazhuang were selected as control group. Enzyme-linked immunosorbent assay （ELISA） was used to detect serum levels of INF- γ and TNF- α, and Positive and Negative Symptom Scale （PANSS） was used to assess the severity of symptoms. Results The level of serum INF- γ （288.36 ＋ 97.84）pg/ml / in the study group were significantly higher than the control group （225.81 ＋ 76.95）pg/ml（t=2.869, P 〈 0.05）, meanwhile the level of serum TNF- α [ （8.59 ± 3.35） pg/ml ] in the study group were significantly higher than the control group [ （5.93 ＋ 2.96）pg/ml （t=3.420, P 〈 0.05）. The serum INF- γ and TNF-α levels were positively correlated with the total score of PANSS, and mainly related to negative symptoms （P 〈 0.05）. Conclusions In the early stages of the onset of schizophrenia, the body had inflammatory reaction activated status. The inflammatory reaction may affect the negative symptoms in schizophrenia during acute phase.

关 键 词：精神分裂症 干扰素-Γ 肿瘤坏死因子-Α 阴性症状 

分 类 号：R379[医药卫生—病原生物学]