血清sST2水平对心衰严重程度危险分层及心功能评估价值  

Value of serum sST2 level in heart failure and heart function evaluation

作　　者：刘清霞 张宏颖[1] 姜辉 LIU Qing-xia;ZHANG Hong-ying;JIANG Hui(Department of Cardiovascular Medicine,the Second People＇s Hospital of Zhengzhou,Zhengzhou,Henan dSO000,China)

机构地区：[1]郑州市第二人民医院心血管内科,河南郑州450000

出　　处：《热带医学杂志》2018年第9期1171-1174,共4页Journal of Tropical Medicine

摘　　要：目的探讨心力衰竭(简称心衰)患者血清可溶性生长刺激表达因子2(sST2)水平对心衰严重程度危险分层及心功能评估价值。方法选取2014年6月至2017年6月间在郑州市第二人民医院接受心力衰竭治疗的患者161例,另选取同期体检健康者90人作为对照组,收集两组人群体质量指数、年龄及性别等基本临床资料,同时收集其早晨空腹静脉血5 mL,常规检测血脂、血糖、肝肾功能等,采用免疫散射比浊法检测血清超敏C-反应蛋白(hsCRP)、胱抑素C(CysC)含量,酶联免疫吸附测定(ELISA)sST2含量,电化学发光免疫分析仪检测N-端脑钠素前体(NT-proBNP)和肌钙蛋白(TnT)含量,计算肾小球滤过率(eGFR)。入院第2天进行心脏彩超检测,收集其左室射血分数(LVEF)、左心室舒张末期的内径(LVEDD)及室间隔厚度(IVST)等。结果心衰组患者血清sST2、尿红细胞、NT-proBNP、血红蛋白、尿素、白细胞及血清肌酐含量均比对照组高,差异有统计学意义(P<0.05);不同心功能级别的心衰患者和对照组在血清TnT、NT-proBNP、CysC、sST2、hs-CRP、eGFR及LVEF、LVEDD间对比差异均有统计学意义(P<0.05);心衰患者LVEDD、LVEF、NT-proBNP、sST2在不同分期间对比差异有统计学意义(P<0.05)。结论心衰患者其血清sST2含量随心功能级别升高而升高,随心衰严重程度增大而增大,可与NT-proBNP协同对患者心功能状况进行评估。Objective To investigate the serum levels of soluble growth- stimulating express gene 2 （sST2） in patients with heart failure on the severity of heart failure risk stratification and cardiac function evaluation. Methods From June 2014 to June 2017, 161 patients had heart failure in Zhengzhou Second People＇s Hospital were enrolled in this study. Totally 90 healthy people in Zhengzhou Second People＇s Hospital were enrolled as the control group. The body mass index, age and gender information were collected. Fasting venous blood samples were collected for the analysis of serum lipids, blood glucose, liver and kidney functions. Immunostaining turbidimetry was used to detect serum hypersensitive C-reactive protenin （hs-CRP） and cystatin C （CysC） content; sST2 content was determined by ELISA; NT-brain natriuretic peptide （NT- proBNP） and troponin T （TnT） content was determined by electrochemiluminescence immunoassay. The left ventricular ejection fraction （LVEF）, left ventricular end-diastolic diameter （LVEDD）, and interventricular septum thickness （IVST） were mesdured. Results The serum levels of sST2, RBC, HGB, urea, WBC and serum creatinine in patients with heart failure were significantly higher than those in control group （P〈0.05）. There was significant difference in the levels of serum TnT, NT-proBNP, CysC, sST2, hs-CRP, eGFR, LVEF and LVEDD between patients with different heart functions and the control group; LVEDD, LVEF, NT- proBNP and sST2 in patients with heart failure had statistically significant differences at different stages （P〈0.05）. Conclusion In patients with heart failure, the level of serum sST2 increased with the increase of cardiac function level and increased with the severity of heart failure. The patients＇ cardiac function status could be evaluated in cooperation with NT-proBNP.

关 键 词：心力衰竭 心功能分级 可溶性ST2 

分 类 号：R541.6[医药卫生—心血管疾病]