复杂天然产物全合成:化学合成与生物合成结合的策略  

Total Synthesis of Complex Natural Products: Combination of Chemical Synthesis and Biosynthesis Strategies

作　　者：李晓军 张万斌[2] 高栓虎 Li Xiaojun1,Zhang Wanbin3,Gao Shuanhu1,2(a Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, Shanghai 200062;b Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University, Shanghai 200062;c School of Chemistry and Chemical Engineering, Shanghai Jiaotong University, Shanghai 20024)

机构地区：[1]华东师范大学化学与分子工程学院上海市绿色化学与化工过程绿色化重点实验室,上海200062 [2]上海交通大学化学化工学院,上海200240 [3]华东师范大学上海分子治疗与新药创制工程技术研究中心,上海200062

出　　处：《有机化学》2018年第9期2185-2185,2186-2198,共14页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.21772044);上海市优秀学术/技术带头人计划(No.18XD1401500);中央高校基本科研业务费资助项目~~

摘　　要：天然产物全合成是有机化学的重要研究方向之一,具有复杂结构和重要生理活性的天然产物及其衍生物也是药物研发的重要来源.主要介绍利用化学合成与生物合成结合的策略,实现复杂天然产物的全合成及规模制备.主要内容包括青蒿素,Spinosyn A,Myceliothernophin E和Equisetin的化学与生物合成研究.Total synthesis of natural products is one of the most important field in organic chemistry. Natural products and derivatives, containing complex structures and potential biological activities, are also indispensable sources of drug discovery.The total synthesis of natural products through the combination of chemical synthesis and biosynthesis strategies is reviewed.The main content includes the chemical and biosynthetic studies of artemisinin, spinosyn A, myceliothernophin E and equisetin.

关 键 词：天然产物全合成 化学合成 生物合成 

分 类 号：O629[理学—有机化学]