趋磁细菌及磁小体的生物医学应用研究进展  

Research Progress on Biomedical Applications of Magnetotactic Bacteria and the Biosynthetic Magnetosomes

作　　者：王方旭 陈玉玲[1,2] 耿读艳 陈传芳[2] WANG Fang-xu1,2, CHEN Yu-ling1,2, GENG Du-yan1, CHEN Chuan-fang2(1. State Key Laboratory of Reliability and Intelligence of Electrical Equipment, Hebei University of Technology,Tianjin 300130, China; 2. Beijing Key Laboratory of Bioelectromagnetism, Institute of Electrical Engineering, Chinese Academy of Sciences, Beijing 100190, China)

机构地区：[1]河北工业大学省部共建电工装备可靠性与智能化国家重点实验室,天津300130 [2]中国科学院电工研究所北京市生物电磁学重点实验室,北京100190

出　　处：《中国生物工程杂志》2018年第9期74-80,共7页China Biotechnology

基　　金：国家自然科学基金(51477169);国家重点研发计划(2017YFC0108501)资助项目

摘　　要：近年来,趋磁细菌及其生物自身合成的磁小体由于良好的生物安全性逐渐被人们所认识,并被用于生物工程和医学应用研究。与人工化学合成磁性纳米颗粒相比,从趋磁细菌中提取的磁小体具有生物膜包被、生物相容性高、粒径均一及磁性高等优势。趋磁细菌因磁小体在其胞内呈链状排列,具有沿磁场方向泳动的能力,也被应用于各种应用研究。因此,综述了趋磁细菌及磁小体特性,并就最近的研究进展重点综述趋磁细菌和磁小体在生物工程及医学应用等领域的最新研究进展。In recent years, magnetotactic bacteria and their biosynthetic magnetosomes have been recognized and have been used in biological and medical applications by people because of their good biosafety.Compared with synthetic magnetic nanoparticles, magnetosomes extracted from magnetotactic bacteria have biomembrane coated,high biocompatibility,uniform particle size and high magnetic. Because magnetotactic bacteria swam along magnetic field,they are also applied in biomedical applications. The characterization of magnetotactic bacterium and magnetosome are first descripted,then reviewed their apllications in biomedical in latest research progress.

关 键 词：趋磁细菌 磁小体 磁纳米颗粒 生物医学应用 

分 类 号：Q7[生物学—分子生物学]