Comb-like Poly(N-(2-hydroxypropyl) methacrylamide) Doxorubicin Conjugates: The Influence of Polymer Architecture and Composition on the Biological Properties  

作　　者：Hao Tang Jin Tang Yi Shen Wen-Xuan Guo Min Zhou Rui-Hua Wang Ni Jiang Zhi-Hua Gan Qing-Song Yu 

机构地区：[1]The State Key Laboratory of Organic-inorganic Composites, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology [2]College of Life Science and Technology, Beijing University of Chemical Technology [3]Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology

出　　处：《Chinese Journal of Polymer Science》2018年第11期1225-1238,共14页高分子科学（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.51503013,51390481,21774008and 81472412);supported by the Fundamental Research Funds for the Central Universities(Nos.ZY1519 and XK1701);the long-term subsidy mechanism from the Ministry of Finance;the Ministry of Education of PRC for BUCT

摘　　要：The synthesis and structure-property correlation of poly（N-（2-hydroxypropyl） methacrylamide） （PHPMA） conjugates with various architectures including random, block, branched or star-like structures and compositions have been thoroughly explored. However, related synthesis and structure-property data are still lacking for comb-like PHPMA. In this work, we report the synthesis of comb-like PHPMA copolymer-doxorubicin （DOX） conjugates with different backbone/side-chain lengths and location of drug moieties. Well-defined comb-like PHPMA-DOX conjugates are obtained via the combination of controlled radical polymerization and fractional precipitation techniques. The influences of structural factors on the biological properties such as cellular uptake, blood circulation and tumor accumulation have been investigated. Long blood circulation and efficient tumor accumulation can be achieved by proper control of the comb number, length and location of drug moieties. These facile comb-like structures possess great potentials in future theranostics for brachytherapy or surgical navigation.The synthesis and structure-property correlation of poly（N-（2-hydroxypropyl） methacrylamide） （PHPMA） conjugates with various architectures including random, block, branched or star-like structures and compositions have been thoroughly explored. However, related synthesis and structure-property data are still lacking for comb-like PHPMA. In this work, we report the synthesis of comb-like PHPMA copolymer-doxorubicin （DOX） conjugates with different backbone/side-chain lengths and location of drug moieties. Well-defined comb-like PHPMA-DOX conjugates are obtained via the combination of controlled radical polymerization and fractional precipitation techniques. The influences of structural factors on the biological properties such as cellular uptake, blood circulation and tumor accumulation have been investigated. Long blood circulation and efficient tumor accumulation can be achieved by proper control of the comb number, length and location of drug moieties. These facile comb-like structures possess great potentials in future theranostics for brachytherapy or surgical navigation.

关 键 词：Poly（N-（2-hydroxypropyl） methacrylamide） Comb-like copolymer Anticancer drug delivery Synthesis Structure-property correlation 

分 类 号：O631.3[理学—高分子化学] TQ460.1[理学—化学]