MPP患儿肺通气功能的变化及孟鲁司特治疗效果观察  

Changes in pulmonary ventilation function in children patients with MPP and effects of montelukast

作　　者：王国毅[1] 杨娜[2] 孙慧玲 Wang Guoyi;Yang Na;Sun Huiling(Depamnent of Pediatrics,the Institutional Hospital of Chengdu Military Command,Chengdu,Siehuan,610011,China;Endoscopy Room,General Hospital of Chengdu Military Command,Chengdu,Siehuan,610083,China)

机构地区：[1]成都军区机关医院儿科,成都610011 [2]成都军区总医院内窥镜室

出　　处：《西南国防医药》2018年第10期910-912,共3页Medical Journal of National Defending Forces in Southwest China

基　　金：成都军区机关第一门诊部院管课题(2015007)

摘　　要：目的探讨肺炎支原体肺炎(MPP)患儿肺通气功能的变化情况,以及孟鲁司特钠的治疗效果。方法将124例MPP患儿随机分为A组(48例)与B组(76例),A组采用阿奇霉素治疗,B组在A组的基础上,加用孟鲁司特钠咀嚼片治疗。分别在在治疗前和治疗第7、14 d,采用呼气相气道内负压法(NEP)测量患儿肺通气功能,比较两组临床治疗效果。结果84.7%的MPP患儿有呼气相流速受限(FL),其中轻度受限占18.6%,中度受限占39.5%,重度受限占26.6%。随着治疗时间的延长,两组呼气相流速受限严重程度均逐渐降低,且B组比A组降低更显著(P <0.05)。治疗后,两组发热时间和住院时间无统计学差异(P> 0.05),但B组肺部罗音持续时间较A组显著缩短(P <0.05)。结论 MPP患儿大多有肺通气功能受损,孟鲁司特联合阿奇霉素治疗有助于提高患儿肺通气功能,减轻临床症状。Objective To explore the changes in pulmonary ventilation function in children patients with mycoplasma pneumoniae pneumonia （MPP） and the effects of montelukast. Methods A total of 124 children patients with MPP were randomly divided into group A （n=48） and group B （n=76）. Group A was treated with azithromycin; and group B was additionally treated with Montelukast Sodium Chewable Tablets. The pulmonary ventilation function in children patients was measured by negative expiratory pressure （NEP） on the 7th and 14th days before and after the treatment to compare the effects between the two groups, Rosttlts Totally 84.7% of children patients with MPP had expiratory flow limitation（FL）, including 18.6% of mild limitation, 39.5% of moderate limitation and 26.6% of severe limitation. With the extension of treatment time, the severity of FL in the two groups gradually decreased; and the decrease in group B was more significant in group A （P 〈 0.05）. After the treatment, the fever time and length of stay showed no statistical difference between the two groups （P 〉 0.05）, but the duration of lung rale in group B was much shorter than that in group A （P 〈 0.05）. Conclusion Most of children patients with MPP have impaired pulmonary ventilation function. Montelukast combined with azithromycin can help to improve the pulmonary ventilation function in children patients and relieve clinical symptoms.

关 键 词：肺炎支原体怖炎 肺通气 呼气流速受限 孟鲁司特 疗效 

分 类 号：R563[医药卫生—呼吸系统]