氢溴酸东莨菪碱的制备  

Preparation of Scopolamine Hydrobromide

作　　者：陈朋朋 吴泽宇 许坤 惠爱玲 张文成 CHEN Pengpeng;WU Zeyu;XU Kun;HUI Ailing;ZHANG Wencheng(Engineering Research Center of Bio-process from Ministry of Education,College of Food Science and Engineering,Hefei University of Technology,Hefei,Anhui 230009,China;Anhui Dexinjia Biological Medicine Co.,Ltd.,Fuyang,Anhui 236000,China)

机构地区：[1]合肥工业大学食品科学与工程学院农产品生物化工教育部工程研究中心,安徽合肥230009 [2]安徽德信佳生物医药有限公司,安徽阜阳236000

出　　处：《农产品加工》2018年第10期13-15,共3页Farm Products Processing

基　　金：安徽省科技重大专项项目<天然东莨菪碱医药中间体的制备及产业化关键技术研究>(16030801111)

摘　　要：选择东莨菪碱含量83%的洋金花提取物为原料,通过加酸成盐和冷冻结晶的方法,制得纯度为99.40%、临床用药的氢溴酸东莨菪碱,并采用DSC、自动旋光仪对样品进行了确证。结果表明,制得的氢溴酸东莨菪碱符合药典中对氢溴酸东莨菪碱的熔点和旋光度的规定。With the flos daturae extract as the raw material （scopolamine purity of 83%） , the preparation of scopolamine hydrobromide was achieved by addition of hydrobromie acid to salt and freezing crystallization. The purity of scopolamine hydro bromide crystals was determined to be 99.40% by high periormanee liquid ehromatograpgy. Meanwhile, the crystals were confirmed by using difterential scanning calorimeter and automatic polarimeter. The resuhs revealed that the prapared scopolamine hydrobromide crystals comply with the pharmacopoeia specification for melting points and optical rotations of scopolamine hydrobromide.

关 键 词：氢溴酸东莨菪碱 冷冻结晶 确证 

分 类 号：R943.4[医药卫生—药剂学]