绒毛栗色鼠尾草根化学成分的研究  

Chemical constituents from the roots of Salvia castanea

作　　者：曹桂云 王秀秀 张良聪 赵爱红[2] 李珂珂[3] 申丽[4] CAO Gui-yun;WANG Xiu-xiu;ZHANG Liang-cong;ZHAO Ai-hong;LI Ke-ke;SHEN Li(Jiangsu Provincial Key Laboratory of Experimental ＆ Translational Non-coding RNA Research,Medical Department,Yangzhou University,Yangzhou 225001,China;School of Life Science and Engineering,Lanzhou University of Technology,Lanzhou 730050,China;Medical Department,Dalian University,Dalian 116622,China;Medical Department,Yangzhou University,Yangzhou 225001,China)

机构地区：[1]扬州大学医学院江苏省非编码RNA基础与临床转化重点实验室,江苏扬州225001 [2]兰州理工大学生命科学与工程学院,甘肃兰州730050 [3]大连大学医学院,辽宁大连116622 [4]扬州大学医学院,江苏扬州225001

出　　处：《中成药》2018年第10期2214-2218,共5页Chinese Traditional Patent Medicine

基　　金：国家自然科学基金面上项目(21372191);江苏省高校自然科学研究面上项目(15KJD360002);江苏省博士后科研自主计划(1501160B)

摘　　要：目的研究绒毛栗色鼠尾草Salvia castanea f. tomentosa Stib.根的化学成分。方法绒毛栗色鼠尾草根70%乙醇提取物采用硅胶、HPLC进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结果从中分离得到11个化合物,分别鉴定为弥罗松酚(1)、柳杉酚(2)、新丹参内酯(3)、6,7-dehydrosempervirol (4)、16,17-二氢睾酮A (5)、△~1-丹参酮Ⅱ_A(6)、1,2-二氢丹参酮Ⅰ(7)、丹参酮Ⅱ_A(8)、丹参内酯A (9)、隐丹参酮(10)、15,16-二氢丹参酮Ⅰ(11)。结论化合物4~6、9、11为首次从该植物中分离得到。AIM To study the chemical constituents from the roots of Salvia castanea f. tomentosa Stib.. METHODS The 70% ethanol extract from the roots of S. castanea was isolated and purified by silica and HPLC, then the structures of obtained compounds were identified by physicochemical properties and spectral data. RESULTS Eleven compounds were isolated and identified as ferruginol （1）, sugiol （2）, neo-tanshinlactone （3）, 6, 7-dehydrosempervirol （4）, 16, 17-dinorpisferal A （5）, △1-dehydromiltirone ⅡA （6）, 1, 2-dihydro- tanshinone Ⅰ（7）, tanshinone ⅡA （8）, tanshinlactone A （9）, cryyptotanshinone （10）, 15, 16-dihydrotanshinone Ⅰ（11） . CONCLUSION Compounds 4 -6, 9 and 11 are isolated from this plant for the first time.

关 键 词：绒毛栗色鼠尾草 根 化学成分 分离鉴定 

分 类 号：R284.1[医药卫生—中药学]