组织蛋白酶V的研究进展  

Research Progress of Cathepsin V

作　　者：侯昕彤 周慧 HOU Xintong;ZHOU Hui(Class 19,Grade 2015,Shenyang Medical College,Shenyang 110034,China;Department of Histology and Embryology)

机构地区：[1]沈阳医学院基础医学院,辽宁沈阳110034 [2]沈阳医学院基础医学院组织学与胚胎学教研室,辽宁沈阳110034

出　　处：《沈阳医学院学报》2018年第5期464-466,共3页Journal of Shenyang Medical College

基　　金：国家自然科学基金(No.81172509);沈阳医学院大学生科研立项(No.20179018);辽宁省级大学生创新创业训练计划项目(No.201710164000024)

摘　　要：组织蛋白酶V (cathepsin V,CTSV)作为半胱氨酸组织蛋白酶家族的一员,在人胸腺、睾丸、乳腺中特异性高表达。CTSV在酸性环境下保持最佳生物活性,参与机体皮肤生长、免疫功能、神经递质产生等多个系统的生物学过程,并与重症肌无力、1型糖尿病、动脉粥样硬化等疾病发病机制密切相关。通过对CTSV的深入了解和研究,可以为今后开发抗肿瘤药物(如乳腺癌和大肠癌等)、治疗免疫疾病及动脉粥样硬化等疾病提供新思路。As a member of the cysteine cathepsins family, cathepsin V is highly expressed in human thymus, testis and breast. Cathepsin V maintains the optimal biological activity in acidic environment. Cathepsin V participates in multiple biological processes such as skin growth, immune regulation and neurotransmitters production, and is closely related to the pathogenesis of myasthenia gravis, type 1 diabetes mellitus and atherosclerosis. Through in-depth understanding and research of cathepsin V, it can provide new ideas for the development of anti-tumor drugs, such as breast cancer and colorectal cancer, and the treatment of immune diseases, atherosclerosis and other diseases.

关 键 词：组织蛋白酶 半胱氨酸蛋白酶 组织蛋白酶V 组织蛋白酶L2 

分 类 号：Q55[生物学—生物化学]