中药熏洗辅助治疗下肢深静脉血栓的疗效及对血液流变学和血流动力学的影响  

Curative effect of traditional Chinese medicine fumigation and washing in the treatment of deep venous thrombosis of lower extremity and its influence on hemorheology and hemodynamic

作　　者：陆南山[1] 邓柏杨[1] 周涛[2] LU Nanshan1 , DENG Baiyang1, ZHOU Tao2(1. Ruikang Hospital, Guangxi University of Traditional Chinese Medicine, Nanning 530001, Guangxi, China; 2. The Second Affiliated Hospital of Shandong University, Jinan 250033, Shandong, China)

机构地区：[1]广西中医药大学附属瑞康医院,广西南宁530001 [2]山东大学第二附属医院,山东济南250033

出　　处：《现代中西医结合杂志》2018年第22期2431-2435,共5页Modern Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的探讨中药熏洗辅助治疗下肢深静脉血栓的临床疗效及对血液流变学和血流动力学的影响。方法将48例下肢深静脉血栓患者随机分为中药熏洗组和对照组,对照组常规给予溶栓配合抗凝、中药辨证治疗,中药熏洗组在对照组治疗基础上结合中药熏洗治疗。对比分析2组患者的临床疗效,治疗前后健患肢体周径差、血液流变学及血流动力学变化。结果治疗2个疗程后,2组大、小腿周径差均较治疗前明显减小(P均<0.05),而组间比较差异无统计学意义(P均>0.05);中药熏洗组治疗前后大、小腿周径差差值明显高于对照组(P均<0.05)。中药熏洗组总体疗效及治愈率均优于对照组(P均<0.05),而2组总有效率比较差异无统计学意义(P>0.05)。2组患者全血低切黏度、血浆黏度、血小板聚集率、纤维蛋白原水平均较治疗前有所降低(P均<0.05),且中药熏洗组治疗后各项指标均明显低于对照组(P均<0.05)。2组患者治疗后SVC、MVO、MVO/SVC、VRT均较治疗前明显升高(P均<0.05),VRT明显延长(P均<0.05),且中药熏洗组治疗后MVO、VRT均明显高于或长于对照组(P均<0.05),而SVC、MVO/SVC值亦高于对照组,但差异无统计学意义(P>0.05)。结论中药熏洗辅助治疗下肢DVT具有良好的短期疗效,不仅能有效改善患者的症状体征,而且对改善局部血管异常也具有重要应用价值。Objective It is to investigate the clinical efficacy of traditional Chinese medicine（ TCM） fumigation and washing in the treatment of deep venous thrombosis（ DVT） of lower extremity and its influence on hemorheology and hemodynamic changes. Methods 48 cases of patients with DVT of lower extremity were randomly divided into TCM fumigation group and control group. The control group was routinely given thrombolytic therapy combined with anticoagulation and TCM syndrome differentiation. The TCM fumigation group was treated with TCM fumigation and washing based on the therapy in the control group. The clinical efficacy of the two groups was compared and analyzed. The changes of peripheral diameter difference between healthy and ill limbs,hemorheology and hemodynamic of the limbs were observed before and after treatment. Results After two courses of treatment,the difference of the circumference between thigh and lower leg was significantly decreased in the two groups compared with that before treatment（ P〈0.05）,but the difference between the groups was not statistically significant（ P〈0.05）; The difference of the diameter difference between the big and the lower leg before and after treatment of TCM fumigation group was significantly higher than that of the control group（ P〈0.05）.The overall efficacy and cure rate of the TCM fumigation group were better than that in the control group（ P〈0.05）,but there was no significant difference in the total effective rate between the two groups（ P〈0.05）. The blood rheology indexes of whole blood low-cut viscosity,plasma viscosity,platelet aggregation rate and fibrinogen were lower than those before treatment in both groups（ P〈0.05）,and the indexes of TCM fumigation group were significantly lower than those of the control group（ P〈0.05）. The hemodynamic parameters of SVC,MVO,MVO/SVC and VRT were significantly higher than those before treatment,and the VRT was significantly prolonged in both groups（ P〈0.05）. The MVO and VRT of t

关 键 词：中药熏洗 深静脉血栓 血液流变学 血流动力学 

分 类 号：R654.4[医药卫生—外科学]