新疆巴州地区慢性乙型肝炎病毒感染者血清标志物模式  

Serum marker pattern of chronic hepatitis B virus infection in Bazhou Area,Xinjiang

作　　者：韩霞 施丽 王路 HAN Xia;SHI Li;WANG Lu(Department of Laboratory,Bazhou People′s Hospital,Korla,Xinjiang 841000,China)

机构地区：[1]新疆维吾尔自治区巴音郭楞蒙古自治州人民医院医学检验科,新疆库尔勒841000

出　　处：《公共卫生与预防医学》2018年第5期119-121,共3页Journal of Public Health and Preventive Medicine

基　　金：自治州科学技术研究("星火")项目:巴州地区乙肝患者荧光定量PCR检测结果与乙肝疗效的分析(201718)

摘　　要：目的统计分析新疆巴州地区慢性乙型肝炎病毒(HBV)感染者不同血清标志物(HBV-M)模式,探讨其感染现状及分布特征。方法收集2016年1月至2017年12月在新疆巴州人民医院检查乙肝5项的就诊者101 202例,采用时间分辨免疫荧光法测定HBV-M,对疑似感染者使用PCR-荧光探针法检测HBV-DNA,分析慢性HBV感染者不同HBV-M模式,及性别、年龄、种族的构成情况。结果 101 202例乙型肝炎5项检测者中,确诊为HBV感染者7 708例,感染检出率为7. 62%,主要表现出15种不同HBV-M组合模式,位于前3位的依次为模式1(HBsAg+,HBe Ab+,HBc Ab+)占70. 52%,模式2(HBsAg+,HBeAg+,HBc Ab+)占12. 65%,模式3(HBsAg+,HBc Ab+)占9. 48%。慢性HBV感染HBsAg阴性者201例,占2. 61%,HBsAg,HBs Ab同时表达阳性者110例,占1. 43%。男性慢性HBV感染者高于女性(P <0. 05),不同年龄、不同族别慢性HBV感染情况不同,差异有统计学意义(P <0. 01)。结论新疆巴州地区乙肝高发,主要表现为HBsAg+,HBe Ab+,HBc Ab+; HBsAg+,HBeAg+,HBc Ab+; HBsAg+,HBc Ab+3种模式。男性多于女性,汉族中青年所占比例较高。Objective To the use of statistics HBV patients’ different HBV - M in Bayingol Prefecture of Xinjiang Province.According to this statistic, discuss infection status and area distribution. Methods Collect 101 202 cases of patients’ healthy information who had checked up in Xinjiang Province Bayingol Prefecture People of hospital from January, 2016 to December, 2017,use TRFTA to test HBV - M, use PCR for suspected patients to test HBV - DNA, analyze chronic HBV infection without HBV - M,and condition of sex, age and race. Results In these 101 202 cases of patients, there are 7 708 cases of patients were diagnosed as HBV. The Infection Detection Rate is 7, 62 percent. It major presents 15 kinds of different HBV - M. And among those, the top of three are type 1 （HBsAg ＋ , HBeAb ＋ , HBcAb ＋ ）, type 2 （（HBsAg ＋ , HBeAg ＋ , HBcAb ＋ ） type 3 （HBsAg ＋ , HBcAb ＋ ）.Type 1 has 70.52 percent. Type 2 has 12.62 percent. Type 3 has 9. 48 percent. Chronic HBV patients with HBsAg who express Ying has 201 cases, and it has 2, 61 percent. Patients with HbsAg, HBsAb who express Yang has 110 cases, and it has 1. 43 percent. Male patients with chronic HBV are more than female patients（P 〈 0. 05）. Different age, race has different the condition of Chronic HBV（P 〈 0. 05）. Difference has statistics significance. Conclusion HBV occurred frequently in the Bayingol Prefecture of Xinjiang Province. It major put up on three types. Male patients are more than female patients. And teenage are in high degree in the Han nationality.

关 键 词：慢性乙型肝炎病毒感染 血清标志物 乙肝病毒 巴州地区 

分 类 号：R183.9[医药卫生—流行病学] R512.6[医药卫生—公共卫生与预防医学]