hs-CRP、LP-PLA2和TPS与高血压合并冠心病的相关性研究  

Correlation of hs-CRP,LP-PLA2 and TPS with hypertension complicated with coronary heart disease

作　　者：黄超 胡良淼 江涛[2] 刘志勇[2] 刘凤恩[2] HUANG Chao;HU Liangmliao;JIANG Tao;LIU Zhi yong;L IU Feng＇en(Department of Cardio＇uascular Medicine,Fifth Hospital of Wuhan City,Wuhan,Hubei 430050,China;Department of Vascular and Mammary Surgery,First Affiliated Hospital of Gannan Medical College,Ganzhou,J iang.xi 341099,China)

机构地区：[1]武汉市第五医院心血管内科,武汉430050 [2]赣南医学院第一附属医院血管乳腺外科,江西赣州341099

出　　处：《国际检验医学杂志》2018年第20期2534-2537,共4页International Journal of Laboratory Medicine

摘　　要：目的探究超敏C反应蛋白(hs-CRP)、血清胰蛋白酶(TPS)、脂蛋白相关磷脂酶A2(LP-PLA2)与高血压合并冠心病的相关性。方法选取2015年11月至2017年11月该院收治的88例高血压合并冠心病患者作为高血压合并冠心病组,50例单纯高血压患者作为单纯高血压组。另选取50例健康体检人员作为对照组。采用高频超声测定颈动脉内膜中层厚度(IMT)并进行冠状动脉Gensini评分,采用酶联免疫吸附试验(ELISA)检测血清hs-CRP、TPS、LP-PLA2水平并分析其与动脉IMT、Gensini评分的相关性。结果高血压合并冠心病组、单纯高血压组、对照组血清hs-CRP、TPS、LP-PLA2水平、颈动脉IMT及冠状动脉Gensini评分依次降低,差异均有统计学意义(P<0.05);血清hs-CRP、TPS、LP-PLA2与颈动脉IMT(r=0.654、0.537、0.556,P<0.05)和Gensini评分(r=0.875、0.954、0.756,P<0.05)呈正相关。结论高血压合并冠心病血清hs-CRP、TPS、LP-PLA2水平均高于单纯高血压患者与健康人群,与颈动脉IMT、Gensini评分均呈正相关提示其可能参与高血压合并冠心病的发生发展过程。Objective To investigate the relationship between hypersensitivity C reactive protein （hs CRP）, serum trypsin （TPS）, lipoprotein associated phospholipase A2 （LP PLA2） and hypertension with coro nary heart disease. Methods Eighty eight cases of patients with hypertension with coronary heart disease,50 cases of simple hypertension in our hospital from November 2015 to November 2017 were selected as hyper tension complicated with coronary heart disease group and simple hypertension group. In addition,50 healthy controls were selected as control group. High frequency ultrasound was used to measure carotid intima media thickness （IMT） and evaluate coronary Gensini score. Serum hs CRP,TPS and LP PLA2 levels were detected by enzyme linked immunosorbent assay （ELISA） ,and their correlation analysis were performed. Results The serum levels of hs CRP,TPS and LP PLA2,carotid artery IMT and coronary artery Gensini score in hyperten sion with coronary heart disease group, simple hypertension group and normal group were decreased in turn, the difference were statistically significant （p〈0.05）. The serum levels of hs CRP,TPS and LP PLA2 were positively correlated with arterial IMT （r=0. 654,0. 537,0. 556,p〈0.000） and Gensini score （r=0. 875, 0.954,0.756,p〈0.05）.Conclusion The levels of serum hs CRP,TPS and LP PLA2 in patients with hyper tension with coronary heart disease were higher than those of simple hypertension and normal subjects, and these levels were positively correlated with carotid IMT and Gensini score, suggesting that they might be in volved in the pathogenesis of hypertension with coronary heart disease.

关 键 词：HS-CRP LP-PLA2 TPS 高血压合并冠心病 

分 类 号：R446.1[医药卫生—诊断学] R541.3[医药卫生—临床医学]