凉山州昭觉县HIV感染者抗病毒治疗效果非治疗因素的影响分析  

Analysis of the Influence of Non Therapeutic Factors on Antiviral Treatment of HIV Infected Patients in Zhaojue County,Liangshan Prefecture

作　　者：马方华[1] 李昌敏[1] 井子伍果 吉好阿雄 Ma Fanghua;Li Changmin;Jing Ziwuguo(Zhaojue County People＇s Hospital Red Ribbon Antiviral Care Center,Liangshan,Siehuan 615000,China)

机构地区：[1]昭觉县人民医院红丝带抗病毒关爱中心,四川凉山615000

出　　处：《四川医学》2018年第9期1007-1010,共4页Sichuan Medical Journal

摘　　要：目的探讨凉山州昭觉县地区影响HIV感染者抗病毒疗效的非治疗因素。方法依据我国指南对纳入的943例HIV感染者进行抗病毒治疗,并进行流行病学调查和治疗随访,比较治疗前后的CD4+T淋巴细胞的改善情况。采用单因素和多因素回归模型分析影响抗病毒效果的非治疗因素。结果单因素和多因素回归结果显示年龄、婚姻状况、感染途径和依从性对患者CD4+T淋巴细胞计数改善情况有显著影响。结论年龄、感染途径、婚姻状况和依从性是影响抗病毒效果的独立非治疗因素。而提高患者依从性是医务人员提高患者抗病毒效果的主要可控手段。Objective To investigate the non-therapeutic factors affecting the anti-viral efficacy of HIV-infected patients in Zhaojue County of Liangshan Prefecture.Methods According to the Chinese guidelines,943 cases of HIV infected people were treated with antiviral therapy,and epidemiological investigation and follow-up were carried out to compare the improvement of CD4＋T lymphocytes before and after treatment.Univariate and multivariate regression models were used to analyze non therapeutic factors affecting antiviral efficacy.Results Univariate and multivariate regression analysis showed that age,marital status,infection pathway and compliance had significant effects on the improvement of CD4＋ T lymphocyte count.Conclusion Age,infection pathway,marital status and compliance are independent non-therapeutic factors affecting antiviral effects.However,improving patient compliance is the main controllable means for medical staff to improve the anti-viral effect of patients.

关 键 词：HIV/ARDS 抗病毒 非治疗因素 依从性 

分 类 号：R512.91[医药卫生—内科学]