孕期母体锌水平与出生缺陷研究进展  

Maternal zinc level and birth defects in offsprings: a review on research progress

作　　者：皮鑫 任爱国[1] PI Xin;REN Ai-guo(Institute of Reproductive and Child Health,Ministry of Health Key Laboratory for Reproductive Health,Department of Epidemiology and Biostatistics,School of Public Health,Peking University,Beijing 100191,China)

机构地区：[1]北京大学生育健康研究所卫生部生育健康重点实验室北京大学公共卫生学院流行病与卫生统计学系,北京100191

出　　处：《中国公共卫生》2018年第10期1430-1433,共4页Chinese Journal of Public Health

基　　金：国家重点研发计划(2016YFC1000501)

摘　　要：锌是维持人体健康的必需微量元素之一,锌不足或缺乏是一个全球性营养问题。近年越来越多的研究表明,孕期母体锌不足或缺乏可能与某些重大出生缺陷存在关联。本文从动物实验证据和人群流行病学资料方面综述母体锌水平与常见重大出生缺陷的发生关系,结果表明,孕期母体锌不足或缺乏可能是先天性心脏病、唇腭裂和神经管缺陷3种重大出生缺陷的危险因素。细胞凋亡和细胞周期紊乱、氧化应激以及细胞信号传导改变为锌不足或缺乏的可能致畸机制。Zinc is an essential trace element. Zinc insufficiency or deficiency is a global nutritional problem. Recently many studies have shown that maternal zinc insufficiency or deficiency during gestation may be associated with several major birth defects. In this review, we summarized the results in the literature regarding the association between maternal zinc level and major birth defects from both animal experiments and human epidemiological studies. It is concluded that maternal zinc insufficiency or deficiency may be a risk factor for congenital heart diseases, orofacial clefts and neural tube defects. The possible teratogenic mechanisms underlying the association include apoptosis and cell cycle disturbances,oxidative stress as well as cell signaling alternation.

关 键 词：锌 先天性心脏病 唇腭裂 神经管缺陷 

分 类 号：R519.1[医药卫生—内科学]