血尿酸和超敏C-反应蛋白与长寿家系的关系  

Relationship between serum uric acid,hypersensitive C-reactive protein and longevity family

作　　者：陈玉柱[1] 方志峰[1] 周为文[1] 黄兆勇[1] 李晓鹏[1] 李忠友[1] 朱婷[1] 韦利玲 唐振柱[1] CHEN Yu-zhu;FANG Zhi-feng;ZHOU Wei-wen;HUANG Zhao-yong;LI Xiao-peng;LI Zhong-you;ZHU Ting;WEI Li-ling;TANG Zhen-zhu(Guangxi Zhuang Autonomous Region Center for Diseuse Control and Prevention,Nanning,Guangxi,210003,China)

机构地区：[1]广西壮族自治区疾病预防控制中心,广西南宁530028

出　　处：《现代预防医学》2018年第19期3577-3580,共4页Modern Preventive Medicine

基　　金：广西壮族自治区卫生计生委自筹课题项目(Z2015458)

摘　　要：目的分析血尿酸、超敏C-反应蛋白与长寿家系的关系。方法选取5个长寿县的90岁及以上长寿老人,并匹配选取其他年龄段的非长寿老人进行横断面调查,817名老人均接受问卷收集基本信息,空腹静脉血测定血尿酸、超敏C-反应蛋白。结果在整个调查人群中,长寿家系血尿酸水平显著高于非长寿家系(t=2. 146,P=0. 016)。非长寿老人中,长寿家系高尿酸血症、高超敏C-反应蛋白患病率与非长寿家系比较差异有统计学意义(χ~2=11. 163、5. 253,P=0. 001、0. 022)。多因素logistic回归分析结果显示,在非长寿老人中,长寿家系患高尿酸血症的风险更高(OR=1. 670,95%CI:1. 054-2. 646),患高超敏C-反应蛋白的风险更低(OR=0. 417,95%CI:0. 193-0. 899)。在长寿老人中,长寿家系和非长寿家系患高尿酸血症和高超敏C-反应蛋白的风险无差别(P=0. 101、0. 435)。结论一定范围的高血尿酸和低超敏C-反应蛋白可能是长寿的有益因素,并可能是长寿遗传的特征指标。Objective To analyze the relationship between serum uric acid （UA）, hypersensitive C - reactive protein （hs - CRP） and longevity family. Methods Long - lived elderly people aged 90 and over in 5 longevity counties were selected, and cross - sectional surveys were conducted for non - long - lived elderly people of other ages. 817 elderly people received basic information from the questionnaire. Fasting venous blood was measured for blood uric acid and hypersensitive C - reactive protein. Results Among the survey population, the blood uric acid level of the longevity family was significantly higher than that of the non - longevity family （ t = 2. 146, P = 0. 016 ）. Among non - long - lived elderly people, the prevalence of hyperurieemia and hypersensitivity C - reactive protein in longevity families was statistically significant compared with non - longevity families. （X^2 = 11. 163, 5. 253, P =0. 001,0. 022）. Multivariate logistic regression analysis showed that long - lived families had a higher risk of hyperuricemia [ OR = 1. 670, 95 % CI（ 1. 054 - 2. 646 ） ] among non - long - lived elderly people, and had a lower risk of developing high - sensitivity C - reactive protein [ OR = 0. 417, 95% CI（ 0. 193 - 0. 899 ） ]. Among long - lived elderly people, there was no difference in the risk of hyperuricemia and hypersensitivity C - reactive protein between longevity and non - longevity families （ P = 0. 101, 0. 435 ）. Conclusion A range of hyperuricemia and low - sensitivity C - reactive protein may be beneficial factors for longevity and may be a characteristic indicator of longevity inheritance.

关 键 词：长寿老人 尿酸 超敏C-反应蛋白 

分 类 号：R113[医药卫生—公共卫生与预防医学]