武汉市海洛因依赖患者美沙酮维持治疗剂量的影响因素  

Methadone dosage and its associated factors in heroin-dependent patients receiving methadone maintenance treatment,Wuhan

作　　者：周聪 钟宝亮[1] 朱军红[1] ZHOU Cong;ZHONG Bao-liang;ZHU Jun-hong(Affiliated Wuhan Mental Health Center,Tongji Medical College of Huazhong University of Science ＆ Technology,Wuhan,Hubei 430012,China)

机构地区：[1]华中科技大学同济医学院附属武汉精神卫生中心,湖北武汉430012

出　　处：《现代预防医学》2018年第19期3613-3616,共4页Modern Preventive Medicine

基　　金：国家自然科学基金面上项目(编号:71774060);武汉市卫生计生科研基金资助(WX17D20;WG16A02)

摘　　要：目的分析武汉市海洛因依赖患者美沙酮维持治疗(Methadone Maintenance Treatment,MMT)剂量的影响因素。方法武汉市3所MMT门诊的549例海洛因依赖患者完成社会人口学特征和临床特征问卷,并收集其MMT剂量、计算BMI指数和用5点口述分级评分法测量患者的疼痛强度。结果 MMT门诊海洛因依赖患者的MMT剂量为(70. 4±29. 2) mg/d,高MMT剂量(≥60 mg/d)患者占比59%。多因素线性回归分析结果显示,年龄20~39岁、BMI正常、BMI超重及肥胖、人际关系一般/差、注射吸毒、吸毒时间> 10年、焦虑和疼痛患者的MMT剂量水平较高。结论武汉市MMT门诊的海洛因依赖患者MMT剂量相对较高。需综合考虑患者的社会人口学、临床和心理因素特征以确定MMT剂量。Objective To examine the methadone dosage and its associated factors in heroin - dependent patients receiving methadone maintenance treatment （MMT） in Wuhan. Methods A total of 549 heroin - dependent patients of three MMT clinics in Wuhan completed the socio - demographic and clinical characteristics questionnaire. Methadone dosage and body mass index （BMI） were collected and calculated, and then pain intensity was assessed with the five -point verbal rating scale. Results The average MMT dosage was （70.4±29.2） mg/d. The proportion of patients taking a high dosage of methadone （≥60 mg/d） was 59%. In multiple linear regression, being aged 20 -39 years, normal BMI, overweight and obesity in BMI, fair/poor interpersonal relationship, injecting heroin, duration of heroin use 〉 10 years, anxiety and pain were significantly associated with a high dosage of methadone. Conclusion The methadone dosage of heroin - dependent patients in MMT clinics in Wuhan is relatively high. Socio - demographic, clinical and psychological factors need to be taken into consideration when determining the dosage of methadone for heroin - dependent patients.

关 键 词：美沙酮维持治疗 剂量 影响因素 

分 类 号：R181.23[医药卫生—流行病学]