绝经妇女激素治疗对心血管疾病的影响  

Effects of postmenopausal hormone therapy on cardiovascular disease

作　　者：刘晓瑷[1] LIU Xiao-ai(International Peace Maternity and Child Health Hospital,Shanghai Jiao Tong University School of Medicine,SHANGHAI 200030,China)

机构地区：[1]上海交通大学医学院附属国际和平妇幼保健院,上海200030

出　　处：《中国新药与临床杂志》2018年第9期I0041-I0046,共6页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：关于绝经妇女激素治疗与心血管疾病风险的研究众多而尚无统一定论,临床观察性研究和大型随机对照研究的结果不一致。通过对妇女健康倡议(WHI)研究和更多设计严谨的研究的数据分析,目前的共识为,对于绝经早期的妇女,即年龄在60岁以内或绝经不足10年者,激素治疗具有心血管保护作用。尼尔雌醇用于绝经妇女激素治疗,同样具有心血管保护作用。There are numerous researches about the effect of postmenopausal hormone therapy on cardiovascular disease but the results are controversial. The results of the observational study are different from that of the randomized controlled trial. Based on the data reanalysis of Women’s Health Initiative study and more well-designed researches, recently consensus confirmed that menopausal hormone therapy is associated with beneficial effects on cardiovascular disease（CVD） when the therapy is initiated 〈 60 years of age and/or 〈 10 years-since-menopause. Nilestriol has the beneficial effects on CVD similarly when used for menopausal hormone therapy.

关 键 词：绝经期 雌激素类 心血管疾病 激素治疗 血脂 

分 类 号：R173[医药卫生—妇幼卫生保健] R977.1[医药卫生—公共卫生与预防医学]