丙型肝炎病毒对ISG产物及干扰素的影响研究进展  

Progress on Effect of Hepatitis C Virus on ISG Products and Interferon

作　　者：王悦萦 马鹏[1] 李林杰[1] 常秋燕 郭富城 李凌浩 马晓霞[1] 马忠仁[1] WANG Yue-Ying;MA Peng;LI Lin-jie;CHANG Qiu-yan;GUO Fu-cheng;LI Ling-hao;MA Xiao-xia;MA Zhong-ren(Gansu Province Animal Cell Research Center,College of LiJe Sciences and Engineering Northwest University For Nationalities,Lanzhou,Gansu,730030,China)

机构地区：[1]西北民族大学生命科学与工程学院/西北民族大学甘肃省动物细胞工程技术研究中心,甘肃兰州730030

出　　处：《动物医学进展》2018年第10期78-82,共5页Progress In Veterinary Medicine

基　　金：中央高校基本科研业务费项目(31920170158);动物医学生物工程创新团队发展计划项目(IRT_17R88)

摘　　要：哺乳动物通过启动细胞内的先天免疫反应来抗击丙型肝炎病毒(HCV)的侵袭和复制。天然免疫防御系统的特点是可以通过病原体识别受体信号介导抗病毒基因产物的表达,包括干扰素和干扰素刺激基因的产生以及感染部位其他促炎细胞因子的分泌来抗击HCV的感染。HCV在人体内持续感染的能力与病毒克服宿主免疫系统的逃避机制有关,HCV还可抵御干扰素治疗的抗病毒反应。对HCV与宿主相互作用的研究揭示了HCV逃避宿主的免疫调节及宿主对HCV免疫调控的机制。论文主要论述在感染HCV的过程中ISG产物的抗病毒作用、HCV对干扰素上、下游的影响及病毒对宿主的逃避机制。Mammalian cells respond to hepatitis C virus （HCV） challenge by initiating an intracellular innate immune response which can limit HCV replication.Innate immune defenses are represented by pathogen recognition receptor signaling which mediates the expression of antiviral gene products, the production of interferon and interferon-stimulated genes, and the secrection of other proinflammatory cytokines from the region of HCV infection.HCV persistence has been linked to a complex combination of virus-host interactions which disrupt intracellular innate immune signaling and resist therapy for HCV infection.The find- ings of the interaction between HCV infection and host defense line can show some molecular mechanisms about immune evasion mediated by ttCV. This paper mainly discussed the antiviral effect of ISG products, the effect of HCV on interferon upstream and downstream, and the evasion mechanism of virus to host in the process of infection of HCV.

关 键 词：先天免疫 丙型肝炎病毒 病原体识别受体分子 信号 干扰素 干扰素诱导基因 

分 类 号：S852.4[农业科学—基础兽医学] S852.659.6[农业科学—兽医学]