绵羊瑞香狼毒中毒病理组织学观察  

Histopathological Observations on Sheep Poisoning of Stellera chamaejasme

作　　者：王兴桂 莫重辉[2] WANG Xing-gui;MO Chong-hui(Huangzhong Animal Husbandry and Veterinary Station,Huangzhong,Qinghai,811600,China;College of Agriculture and Animal Husbandry,Qinghai University,Xining,Qinghai,810016,China)

机构地区：[1]青海省湟中县畜牧兽医工作站,青海湟中811600 [2]青海大学农牧学院,青海西宁810016

出　　处：《动物医学进展》2018年第10期126-129,共4页Progress In Veterinary Medicine

基　　金：公益性行业(农业)科研专项项目(20123062);青海省科技厅科技创新能力促进计划项目(2014-ZJ-771)

摘　　要：为了观察试验羊瑞香狼毒中毒后病理组织学变化,将8只试验羊分为2组,每天分别按2.5g/kg和5g/kg体重的剂量投服瑞香狼毒干草粉,在试验第32天剖检并观察各组织器官病理组织学变化。结果表明,所有试验羊在试验期间均表现腹泻、饮水量增加等临床症状,且高剂量组试验羊腹泻较为严重,最后表现出神经症状而死亡。剖检变化主要表现为极度消瘦,肠壁充血,胃壁薄,黏膜脱落,出血,肺气肿,心室血凝不良,肝边缘钝化,质脆易碎,肾肿大,皮质部变薄等。病理组织学变化主要表现为心肌纤维肿胀变性,结构紊乱,横纹消失;细支气管扩张,肺泡壁毛细血管扩张充血;肾小球明显肿大,毛细血管内皮细胞增生,肾球囊间隙变窄,肾小管上皮细胞肿胀、变性,肾小管管腔狭窄或阻塞;肝细胞肿大,肝细胞颗粒变性,窦状隙狭窄或阻塞,中央静脉极度扩张;大脑组织间隙血管充血明显,局部出血,神经细胞变性坏死,出现噬神经元现象。In order to observe the histopathological lesions after the poisoning of the sheep with Stellera charnaejasrne,eight healthy adult sheep were randomly divided into two groups, which were fed with Stellera chamaejasme powder at 2.5 g/kg and 5.0 g/kg for each body weight everyday.Autopsy and histopathological lesions were observed on the 32 day of the test.The results showed that all sheep appeared symptoms of diarrhea and increasing drink,and the diarrhea in high-dose group was more severe than that in low-dose group. Finally, sheep appeared neurologic symptoms and death. Autopsy change showed extremely thin,intestinal wall congestion and thin, the stomach mucous membrane shedding and bleeding, emphysema, ventricular blood clotting adverse, liver edge blunt, qualitative fragile, renal enlargement, cortical thinning, etc.The histopathological lesions showed myocardial fibrosis and swelling, structural disorder, horizontal striation disappeared, bronchiectasis, alveolar wall capillary congestion.The glomeruli are obviously swollen, the capillary epithelial cells proliferate, the gap of the renal balloon is narrowed, and the renal tubular epithelium is swollen, denatured, and the lumen is narrow or obstructed. Hepatocyte enlarge- ment,sinus stenosis or obstruction, central venous distension, hepatic cell granule degeneration. Cerebral blood vessels in the brain are hyperemic,local hemorrhage,neuronal degeneration necrosis and autophagy.

关 键 词：瑞香狼毒 病理组织学 有毒植物 羊 

分 类 号：S859.87[农业科学—临床兽医学] S852.31[农业科学—兽医学]