血清D-木糖与太阴病(脾阳虚证)“欲解时”及理中汤干预的研究  

Study on serum D-xylose changes in the recovery of Taiyin disease (syndrome of spleen yang deficiency) and after the intervention of Lizhong Decoction

作　　者：张广梅[1] 李杰[1] 吴萍[1] 张发斌[1] 赵协慧[1] 王仁嫒[1] 杨艳[1] 陈湘宏[1] 刘占厚[1] ZHANG Guang-mei;LI Jie;WU Ping;ZHANG Fa-bin;ZHAO Xie-hui;WANG Ren-ai;YANG Yah;CHEN Xiang-hong;LIU Zhan-hou(Medical College of Qinghal University,Xining 810001,China)

机构地区：[1]青海大学医学院,西宁810001

出　　处：《中华中医药杂志》2018年第10期4685-4688,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金项目(No.81360520)~~

摘　　要：目的:探讨血清D-木糖在太阴病(脾阳虚证)欲解时以及理中汤干预后的变化。方法:健康未孕SD大鼠1 824只,随机分为正常组(n=480)、模型组(n=672)、药物组(n=672)。模型组采用大承气汤灌胃法造脾阳虚模型。造模成功后,药物组在子时、午时灌胃理中汤,连续12d。造模结束及药物干预的同时,每天分别于子时、午时及卯时、酉时从各组中各抽取10～14只大鼠获取血清标本,观察血清D-木糖的变化。结果:模型组血清D-木糖低于正常组,经子时、午时给予理中汤治疗后,血清D-木糖值升高,尤于子时明显。结论:太阴病脾阳虚证大鼠经理中汤治疗后,血清D-木糖值子时升高明显,与张仲景《伤寒论》太阴病欲解时相符合。Objective： To explore the variation of serum D-xylose in the recovery of Taiyin disease （syndrome of spleen yang deficiency） and after intervention by Lizhong Decoction. Methods： Healthy non-pregnant SD rats 1 824, randomly divided into normal group （n=480）, model group （n=672） and drug group （n=672）. In the model group, the model of deficiency of spleen yang was established by using Dachengqi Decoction by gavage. After successful modeling, the drug group was given gastric lavage Lizhong Decoction in the period of the day from 23：00 to 1：00, 11：00 to 13：00. for 12 consecutive days. At the end of modeling and drug intervention at the same time, in the period of the day from 23：00 to 1：00, 11：00 to 13：00, 5：00 to 7：00 and 17：00 to 19：00 everyday respectively, from normal group, model group and drug group, 10-14 rats were taken from each group to get serum samples, mad observe the changes of serum D-xylose. Results： The serum D-xylose of model group was lower than that of the normal group, after the treatment with Lizhong Decoction in the period of the day from 23：00 to 1：00, 11：00 to 13：00 the serum D-xylose value increased, especially in the period of the day from 23：00 to 1：00. Conclusion： After the treatment with Lizhong Decoction of rats of Taiyin disease, syndrome of spleen yang deficiency, the serum D-xylose value was increased significantly, which accorded with ZHANG Zhong-jing＇s theory of ＇the recovery of disease＇ in Taiyin.

关 键 词：太阴病 欲解时 D-木糖 理中汤 脾阳虚证 

分 类 号：R285.5[医药卫生—中药学]