星蒌承气汤治疗急性缺血性中风病痰热腑实证的临床观察  

Effects of Xinglou Chengqi Decoction for acute ischemic stroke with syndrome of phlegm-heat and fu-organ excess

作　　者：陈沛[1] 江澜[1] 韩笑[1] 徐寅平 陈彦[3] 张龙生[4] 郭晋斌 邹忆怀[1] CHEN Pei;JIANG Lan;HAN Xiao;XU Yin-ping;CHEN Yan;ZHANG Long-sheng;GUO Jin-bin;ZOU Yi-huai(Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine,Beijing 100700,China;Beijing Pinggu Hospital of Traditional Chinese Medicine,Beijing 101200,China;Beijing Changping Hospital of Traditional Chinese Medicine,Beijing 102200,China;Dongzhimen Hospital Eastern Affiliated to Beijing University of Chinese Medicine,Beijing 101100,China;Hospital Affiliated to Changzhi Academy of Chinese Medical Sciences,Changzhi 046000,China)

机构地区：[1]北京中医药大学东直门医院,北京100700 [2]北京中医医院平谷医院,北京101200 [3]北京市昌平区中医医院,北京102200 [4]北京中医药大学东直门医院东区,北京101100 [5]长治市中医研究所附属医院,山西长治046000

出　　处：《中华中医药杂志》2018年第10期4764-4767,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家"十二五"科技支撑计划项目(No.2013BAI13B02)~~

摘　　要：目的:从中医证候及神经功能角度,探讨星蒌承气汤治疗急性缺血性中风病痰热腑实证患者的临床效应特点。方法:采用多中心、前瞻、随机对照研究方式,纳入急性缺血性中风病痰热腑实证患者315例,随机分为治疗组210例及对照组105例。在西医常规治疗基础上,治疗组加服星蒌承气汤,对照组采用杜密克口服和(或)开塞露灌肠。疗程(5±2)d,治疗前后对患者进行量表评价。结果:两种疗法对内风、内火、痰湿、血瘀证候要素,痰热腑实证及神经功能均具有改善作用(P﹤0.01),但仅治疗组可改善患者的气虚、阴虚(P﹤0.05,P﹤0.01),并且对痰热腑实证的疗效优于对照组(P﹤0.05)。结论:星蒌承气汤对急性缺血性中风病痰热腑实证有较好的改善作用,同时对患者的气阴具有固护作用。Objective： To study the effects of Xinglou Chengqi Decoction for acute ischemic stroke with syndrome of phlegm-heat and fu-organ excess from the point of neurological impairment and traditional Chinese medicine syndrome. Methods： This study was designed as a multi-center, prospective, randomized controlled trial. A total of 315 qualified subjects were enrolled and randomized to the study group （210 subjects） and control group （105 subjects）. Except for the conventional treatment for stroke, subjects in the study group were treated with Xinglou Chengqi Decoction, while the control group received clysis therapy using glycerineenemas and/or oral administration of lactulose solution. The treatment period varied within （5±2） days. Assessments were conducted before and after treatment. Results： Both therapies effectively relieved the inner wind, inner fire, phlegm and blood-stasis, together with syndrome of phlegm-heat and fu-organ excess and neurological impairment （P〈0.01）. However, only Xinglou Chengqi Decoction benefited qi and yin deficiency （P〈0.05, P〈0.01） and it outperformed the control therapy in relieving the syndrome of phlegm-heat and fu-organ excess （P〈0.05）. Conclusion： Xinglou Chengqi Decoction could effectively attenuate syndrome of phlegm-heat and fu-organ excess and benefit qi and yin.

关 键 词：急性缺血性中风病 星蒌承气汤 痰热腑实证 化痰通腑法 

分 类 号：R277.7[医药卫生—中医学]