屈螺酮炔雌醇片对人工流产术后出血、月经周期及意外妊娠情况的影响  

The influence of drospirenone and ethinyl estradiol on hemorrhage, menstrual cycle and accidental pregnancy after induced abortion

作　　者：李常虹 张林静[1] 陈惠丽[1] LI Changhong;ZHANG Linjing;CHEN Huili(Department of Obstetrics and Gynecology,Hainan Province,Haikou,the Maternal and Child Health Hospital of Hainan 570206,China)

机构地区：[1]海南省妇幼保健院妇产科,海南海口570206

出　　处：《徐州医科大学学报》2018年第9期601-605,共5页Journal of Xuzhou Medical University

基　　金：海南省自然科学基金（811160）

摘　　要：目的探讨屈螺酮炔雌醇片对人工流产术后阴道出血、月经周期及意外妊娠情况的影响。方法选择行人工流产术的366例患者为研究对象，根据患者术后是否口服短效复方避孕药屈螺酮炔雌醇片分为观察组（n=190）和对照组（n=176）。观察组患者人工流产术后给予屈螺酮炔雌醇片进行避孕；对照组患者采用其他方式进行避孕。比较2组患者人工流产术后阴道出血、月经周期、意外妊娠及生殖激素水平变化情况和并发症发生情况。结果观察组患者人工流产术后的阴道出血时间、出血量和阴道分泌物增多的比例均显著低于对照组（P〈0．05）。观察组患者人工流产术后月经复潮时间和月经恢复情况均明显优于对照组（P〈0．05）。观察组患者术后3周的子宫内膜厚度显著高于对照组，而闭经、痛经、经前期综合征和术后6个月内再次妊娠的比例均显著低于对照组（P〈0．05）。观察组患者人工流产术后雌二醇（E2）上升程度，黄体生成素（LH）和孕激素（PRL）下降程度均显著高于对照组（P〈0．05）。观察组患者术后并发症发生率均低于对照组患者（P〈0．05）。结论人工流产术后应用屈螺酮炔雌醇片可显著减少阴道出血，帮助子宫内膜修复和月经周期恢复，且避孕效果好，并发症少，值得在临床推广应用。Objective To investigate the effect of drospirenone and ethinyl estradiol on vaginal bleeding, menstrual cycle and accidental pregnancy after induced abortion. Methods A total of 366 patients who underwent induced abortion were selected in this study. According to whether short - acting compound oral contraceptive drospirenone and ethinyl es- tradiol was given after abortion, patients were divided into observation group （n = 190 ） and control group （n = 176 ）. The patients in the observation group were given drospirenone and ethinyl estradiol for contraception after induced abor- tion. The patients in the control group received other methods of contraception. The changes of vaginal bleeding, men- strual cycle, accidental pregnancy, reproductive hormone levels, and complications were compared between the two groups. Results The vaginal bleeding time, bleeding amount and proportion of increased vaginal secretion after abortion in the observation group were significantly lower than those in the control group （ P 〈 0.05 ）. The recovery time of men- struation and menstrual recovery after abortion in the observation group were significantly better than those in the control group （ P 〈 0.05 ）. The endometrial thickness 3 weeks after abortion was significantly higher in the observation group than in the control group, while the proportion of amenorrhea, dysmenorrheal, premenstrual syndrome, and repeated pregnan- cy within six months after abortion in the observation group were significantly lower than that in the control group （ P 〈 0.05 ）. The degree of rising in estradiol level after abortion in the observation group was significantly higher than that in the control group, while the degree of decline in luteinizing hormone and progesterone levels was significantly higher than that in the control group （ P 〈 0.05 ）. The incidence of complications after abortion in the observation group was signifi- cantly lower than that in the control group （ P 〈 0.05 ）. Conclusions Drospirenone an

关 键 词：人工流产 避孕 复方短效口服避孕药 阴道出血 生殖激素 

分 类 号：R719[医药卫生—妇产科学]