创伤性急性肺损伤分子机制研究进展  

Advances in molecular mechanisms of traumatic acute lung injury

作　　者：高二击 李扬[1] 赵天成[1] 郭翔[1] 何伟伟[1] 杨异 GAO Erji;LI Yang;ZHAO Tiancheng;GUO Xiang;HE Weiwei;YANG Yi(Department of Thoracic Surgery,Shanghai Sixth People＇s Hospital Affiliated to Shanghai Jiao Tong University,Shanghai 200233,China)

机构地区：[1]上海交通大学附属上海市第六人民医院胸外科,上海200233

出　　处：《徐州医科大学学报》2018年第9期626-630,共5页Journal of Xuzhou Medical University

摘　　要：目的急性肺损伤（ acute lung injury,ALI）是指由肺炎、吸入损伤和创伤等因素导致的急性的、进行性的肺毛细血管内皮细胞和肺泡上皮细胞损伤，肺挫伤是其病程的早期阶段。而肺挫伤如治疗不及时患者往往进展为急性呼吸窘迫综合征（ acute respiratory distress syndrome, ARDS），其死亡率高达30％-60％。但目前针对创伤性急性肺损伤仍然缺乏足够的研究。本文通过搜集近年来相关文献，对血清学标志物与创伤性急性肺损伤的发病关系进行综述，为其早期诊治及后续研究提供线索。Acute lung injury （ALI） is an acute and progressive respiratory failure state which can be induced by pneumonia, aspiration and trauma. Lung contusion is the early phase of traumatic ALI. ALI sometimes progresses to a- cute respiratory distress syndrome （ARDS） for a delayed management and the mortality rate may be as high as 30% - 60%. But there are no sufficient studies about ALI following trauma. We made this review about biomarkers of traumatic ALI after searching recent related literatures systematically, in order to provide a clue for early diagnosis and further re- search of ALI.

关 键 词：创伤 急性肺损伤 肺挫伤 标志物 发病机制 

分 类 号：R641[医药卫生—外科学]