1763例妊娠期女性宫颈HPV感染情况分析  

Analysis on infection status of cervical human papillomavirus in 1 763 pregnant women

作　　者：纪巍 张晓瑜 张邂方 JI Wei;ZHANG Xiaoyu;ZHANG Xiefang(Eugenics Center,210 Hospital of PLA,Dalian,Liaoning 116021,China)

机构地区：[1]中国人民解放军第二一〇医院优生优育中心,辽宁大连116021

出　　处：《检验医学与临床》2018年第20期3041-3042,3045,共3页Laboratory Medicine and Clinic

摘　　要：目的了解妊娠期女性宫颈人乳头瘤病毒(HPV)感染情况和基因分型的分布情况。方法采用HPV分型基因芯片检测系统对2014年11月至2017年8月在该院门诊就诊的1 763例孕妇进行HPV基因分型检测,分析妊娠期HPV的感染率及分型的分布特点。结果 1 763例孕妇中检出HPV感染者489例,阳性率为27.74%,其中HPV高危亚型411例,占阳性感染者的84.05%;单纯低危亚型45例,占阳性感染者的9.20%;高低混合感染33例,占阳性感染的6.75%。感染率较高的高危型是HPV58、52、16、53,感染率较高的低危型是HPV6和HPV54。双重及双重以上亚型感染者84例,占感染者的17.18%。结论妊娠期女性HPV高危型与单一型感染率较高。Objective To understand the infection situation and genotype distribution situation of cervical human papillomavirus（HPV）among pregnant women.Methods The HPV genotyping microarray detection system was adopted to detect the HPV genotype among 1 763 pregnant women in outpatient department of this hospital from November 2014 to August 2017.The HPV infection rate and genotype distribution characteristics were analyzed.Results Among 1 763 pregnant women,489 cases of HPV infection were detected with the positive rate of 27.74%,in which 411 cases were high risk infection of HPV,accounting for 84.05%of positive infection cases;45 cases were simple low risk genotypes,accounting for 9.20% of positive infection cases;33 cases were high-low risk mixed infection,accounting for 6.75% of positive infection cases.The high risk genotypes of HPV with the high infection rate were HPV58,52,16,53;the low risk genotypes were HPV6 and HPV54.Eighty-four cases were dual and more than dual subtype infection,accounting for 17.18%of positive infection cases.Conclusion The infection rates of high risk genotype and single geno type of HPV are higher among pregnant women.

关 键 词：人乳头瘤病毒 妊娠期 女性 感染率 

分 类 号：R446.1[医药卫生—诊断学]