激光诱导气泡堵塞血管治疗增生性血管皮肤病的实验研究  

Experimental Study on Laser Induced Bubble Occlusion of Blood Vessels in Treatment of Proliferative Vascular Dermatosis

作　　者：贾浩[1] 陈斌[1] 邢林庄[1] 李东[1] 应朝霞[2] JIA Hao;CHEN Bin;XING Lin-Zhuang;LI Dong;YING Zhao-Xia(State Key Laboratory of Multiphase Flow in Power Engineering,Xi,an Jiaotong University,Xi,an 710049;Laser Treatment Center,Department of Dermatology,Medical School,Xi,an Jiaotong University,Xi,an 710049,China)

机构地区：[1]西安交通大学动力工程多相流国家重点实验室,西安710049 [2]西安交通大学第二附属医院皮肤科激光诊疗中心,西安710004

出　　处：《工程热物理学报》2018年第10期2223-2228,共6页Journal of Engineering Thermophysics

基　　金：国家自然科学基金重点项目(No.51336006)

摘　　要：为探究激光诱导气泡膨胀堵塞病变血管治疗血管增生性皮肤病的机理,本文建立大鼠鼠脊视窗荧光显微观测系统,研究了脂质体微粒注射前后,中等能量多脉冲1064 nm激光照射血管的热响应和血液中气泡产生、发展的现象。研究发现,血液中的脂质体微粒可成为额外的汽化核心,降低气泡形成的温度阈值,使得气泡产生的概率由未注射的10%显著增大到了注射后的52%。气泡产生后可于15 min内膨胀至最大体积并长时间堵塞血管,会使血管壁因缺氧而坏死。In order to explore the mechanism of laser induced bubble occlusion of vascular lesions in treating proliferative vascular dermatosis, we established a fluorescence microscopic observation system based on the dorsal skin chamber model. Thermal responses of blood vessel and bubble＇s generation and development were investigated under multi-pulse 1,064 nm laser irradiation with moderate energy density before and after liposome injection. The results showed that liposomes in blood can be additional nucleation to decrease temperature threshold of bubble formation, thus bubble generation probability increases obviously from 10% to 52% after liposome injection. After produced, bubbles can expand to the maximum volume in 15 min and occlude the blood vessels for a long time, causing the vascular wall necrosis by hypoxia.

关 键 词：激光皮肤手术 血管热效应 气泡堵塞 脂质体纳米颗粒 多脉冲激光 

分 类 号：TK124[动力工程及工程热物理—工程热物理] TK121[动力工程及工程热物理—热能工程]