丝素蛋白基药物缓释功能肠道支架的研制  

Study of Silk Fibroin-Based Colorectal Stents with Drug Delivery Function

作　　者：谢旭升 李刚[1,2] 王晓沁 赵泽宇[1,2] 李翼 兰平[4] XIE Xusheng;LI Gang;WANG Xiaoqin;ZHAO Zeyu;LI Yi;LAN Ping(a.College of Textile and Clothing Engineering/b.National Engineering Laboratory for Modern Silk,1.Soochow University,Suzhou 215123,China;School of Materials,The University of Manchester,Manchester M13 9 PL,UK;Department of Colorectal Surgery,The Sixth Affiliated Hospital of Sun Yat-Sen University,Guangzhou 510655,China)

机构地区：[1]苏州大学纺织与服装工程学院,江苏苏州215123 [2]苏州大学现代丝绸国家工程实验室,江苏苏州215123 [3]曼切斯特大学材料学院 [4]中山大学附属第六医院结直肠外科,广东广州510655

出　　处：《东华大学学报（自然科学版）》2018年第5期749-754,共6页Journal of Donghua University(Natural Science)

基　　金：国家自然科学基金资助项目(51603140);国际中德科学基金研究资助项目(GZ1094);江省高校自然科学研究面上资助项目(16KJB540003);苏州市科技计划重点产业技术创新资助项目(SYG201638);江苏省自然科学青年基金资助(BK20150372)

摘　　要：临床上,对于急诊手术风险大或者多发转移等结直肠癌患者,放置肠道支架可解除梗阻,进行姑息治疗后再配合化疗等辅助治疗手段,是一个有效的治疗思路。开发了具有良好生物相容性、可降解、可局部给药等性能的新型复合肠道支架,其内层为采用纬编工艺制备的聚二氧六环酮(PDO)可降解裸支架,外层为采用烘干成膜工艺制备的丝素蛋白搭载姜黄素药膜。对该支架的力学性能,药膜的微观形貌、二级结构、晶体结构和药物缓释性能进行了研究。结果表明,最佳药膜的丝素蛋白质量分数为15%、聚乙二醇(PEG-400)与丝素蛋白溶液的质量配比为1∶3(姜黄素的质量分数为0.125%)、温度为80℃。3种载药量不同的药膜在200h左右内持续释放,400h达到药物最高释放浓度,其中,药物最高累积释放质量浓度为(13.32±0.80)mg/L,最高累积释放率为(98.67±5.93)%。因此,丝素蛋白基药物缓释功能肠道支架在治疗结直肠患者过程中具备一定的潜在价值。Clinicaly, stents combining radio-chemotherapy is an effective palliative treatment for colorectal cancer patients with advanced disease, high emergent surgical risk, multiple transfer rate and in poor general health. A new intestinal stent with good compatibility, degradability and local delivery ability was developed. The inner layer of the degradable stent was knitted by polydioxanone（PDO） monofilament; the outer was prepared by silk fibroin membrane with curcumin. The morphology, chemical structure, mechanical properties and in vitro drug release property of stents were studied, respectively. The result shows that the optimal model of silk fibroin mass fraction is 15%, the mass ratio of polyethylene glycol（PEG-400） to silk fibroin is 1 ： 3 （mass fraction of curcumin was 0. 125%） and

关 键 词：结直肠癌 支架 聚二氧六环酮 姜黄素 丝素蛋白 

分 类 号：TS141.8[轻工技术与工程—纺织材料与纺织品设计]