代谢组学在糖尿病研究中的应用  

Application of metabonomics in diabetic research

作　　者：杨雪[1] 韦晓[1] 杨婉薇[1] 陈国芳[1] 刘超[1] Yang Xue;Wei Xiao;Yang Wanwei;Chen Guofang;Liu Chao(Department of Endocrinology and Metabolism,Affiliated Hospital of Traditional Chinese and West-ern Medicine,Nanjing University of Traditional Chinese Medicine,Jiangsu Branch of China Academy of Chinese Medical Science,Nanjing 210028,China)

机构地区：[1]南京中医药大学附属中西医结合医院内分泌代谢病院区,江苏省中医药研究院,210028

出　　处：《国际内分泌代谢杂志》2018年第5期343-346,共4页International Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金（81600600）

摘　　要：糖尿病是以糖、脂代谢紊乱为主要表现的代谢性疾病,其并发症导致致死率和致残率极高.目前糖尿病确切的发病机制仍未可知,也未见有效的根治方法.代谢组学作为一种能够识别和测量生物体代谢变化的新技术,可以揭示机体生命活动的代谢本质,其在糖尿病疾病预测、疾病诊断、发病机制和药物疗效评价方面发挥重大作用,其主要的检测手段包括核磁共振与质谱技术.Diabetes mellitus is a metabolic disease which mainly characterized by glucose and lipid metabolism disorders,and its complications lead to extremely high mortality and disability.The exact pathogenesis of diabetes is still unknown,and there is no effective cure.As a new technology,metabonomics can identify and measure metabolic changes in organisms,reveal the metabolic nature of organisms,vital movement.It plays a major role in the prediction,diagnosis,pathogenesis and drug efficacy of diabetes mellitus.Detection methods of metabolomics include nuclear magnetic resonance and mass spectrometry techniques.

关 键 词：代谢组学 糖尿病 代谢性疾病 

分 类 号：R587.1[医药卫生—内分泌]