细颗粒物对糖尿病的影响  

Effects of fine particulate matter on diabetes mellitus

作　　者：蔡思嘉 徐晓蒙[1] 邱轩[1] 刘宽芝[1] Cai Sijia;Xu Xiaomeng;Qiu Xuan;Liu Kuanzhi(Department of Endocrinology,The Third Hospital of Hebei Medical University,Shijiazhuang 050051,China)

机构地区：[1]河北医科大学第三医院内分泌一科,石家庄050051

出　　处：《国际内分泌代谢杂志》2018年第5期347-349,共3页International Journal of Endocrinology and Metabolism

摘　　要：日趋严重的空气污染已经成为危害健康的主要因素之一,近年来,细颗粒物被广泛关注.研究表明,空气污染与2型糖尿病发病的关系十分密切,其中以细颗粒物（PM2.5）的影响最为显著.PM2.5颗粒小,吸附性强,不仅可以诱发呼吸系统疾病,还可以诱发或加重糖尿病及心血管疾病.PM2.5可通过引起胰岛素抵抗、内皮细胞损伤、氧化应激、炎性反应等机制促进糖尿病的发生和病情的加重.对两者间关联的研究有助于防治糖尿病.The increasingly serious air pollution has become one of the major health hazards.In recent years,fine particulate matters have become widely concerned.Studies showed that the relationship between air pollution and incidence of type 2 diabetes mellitus was very strong.The effect of fine particulate matters （PM2.5） is the most significant.PM2.5 are small,strong absorbtion.They can not onlyinduce respiratory diseases,but also induce or aggravate diabetes and cardiovascular diseases.PM2.5 can promote the development of diabetes and increase the severity of the disease by inducing insulin resistance,endothelial cell injury,oxidative stress and inflammatory reaction.The study of their relationships is helpful for the prevention and treatment of diabetes.

关 键 词：空气污染 胰岛素抵抗 氧化应激 内皮功能紊乱 糖尿病 

分 类 号：R587.1[医药卫生—内分泌]