沙眼衣原体持续感染的研究进展  

Research Progress on Chlamydia Trachomatis Persistent Infection

作　　者：刘勇[1] 边鹊桥[1] LIU Yong;BIAN Queqiao(Department of Dermatology ＆ STD,Tianjin Third Central Hospital,Tianjin 300170,China)

机构地区：[1]天津市第三中心医院皮肤性病科,天津300170

出　　处：《医学综述》2018年第19期3834-3840,共7页Medical Recapitulate

摘　　要：沙眼衣原体持续感染是指在不利生长条件下产生的一种可逆状态。持续感染状态下的沙眼衣原体有活力,但呈肿大的异常型,且新陈代谢处于静止状态。包括营养缺乏,合并病毒感染、噬菌体、抗生素效应、细胞因子,疾病和个体及男女差异在内的多种因素都可导致沙眼衣原体持续感染。沙眼衣原体持续感染迁延难愈并可导致严重并发症,故成为目前沙眼衣原体研究的热点。近年来,随着对沙眼衣原体持续感染的不断深入研究,抗生素联合应用、乳胞素、色氨酸分解酶抑制剂等新型药物、免疫调节剂、新型疫苗及噬菌体成为治疗沙眼衣原体的新手段。Chlamydial persistent infection is a reversible state generated during conditions deleterious to growth. In persistent infection, Chlamydia trachomatis remains viable but atypical, with an enlarged, aberrant form and quiescent metabolism. Several factors including the presence of nutritional deficiency, virus infection, phage, antibiotic effects, cytokines, other diseases,individual and gender difference could contribute to chlamydial persistent infection. Chlamydia persistent infection is difficult in treatment and can cause serious complications, which is the focus of the research. In recent years, with the continuous study of chlamydia infection, combined use of antibiotics, new drugs such as lactoin and tryptophan lyase inhibitors, immune regulation,new vaccines and phages have become new methods for the treatment of chlamydia trachomatis.

关 键 词：沙眼衣原体 持续感染 分子机制 

分 类 号：R374.1[医药卫生—病原生物学]