不同一线ART治疗方案治疗艾滋病的抗病毒效果分析  

Analysis of Antivirus Effect of Different First-line ART Treatment Programs for AIDS

作　　者：张亚武 ZHANG Yawu(STD AIDS Department,Wuhan City Jinyintan Hospital,Wuhan Hubei 430012,China)

机构地区：[1]武汉市金银潭医院性病艾滋病科,湖北武汉430012

出　　处：《中国继续医学教育》2018年第30期140-142,共3页China Continuing Medical Education

摘　　要：目的探讨不同一线艾滋病抗病毒治疗(ART)治疗方案对艾滋病的抗病毒作用。方法抽取我院2005年2月—2018年2月经治的80例艾滋病感染者为研究对象,根据治疗方式分为两组。对照组采用替诺福韦+拉米夫定+奈韦拉平,给予观察组齐多夫定+拉米夫定+依非韦伦治疗方案,比较两组治疗效果。结果两组治疗3个月、6个月和9个月时CD4+淋巴细胞计数差异无统计学意义(P> 0.05),同组不同时间段对应指标对比,差异具有统计学意义(P <0.05);对照组治疗3个月、6个月和9个月后的转阴率对比,差异无统计学意义(P> 0.05)。结论不同一线ART治疗方案治疗艾滋病效果明显。Objective To explore the antiviral effect of different first-line HIV treatment （ART） treatment on AIDS. Methods 80 cases of patients with AIDS who were treated in our hospital from February 2005 to February 2018 were selected and divided into two groups according to the treatment methods. The control group was treated with tenofovir, lamivudine combined with nevirapine. The observation group was treated with zidovudine, lamivudine combined with efavirenz, and the therapeutic efects of the two groups were compared. Results There was no signifcant diference in CD4 ＋ lymphocyte count between the two groups at 3, 6 and 9 months after treatment （P 〉 0.05）. There was a significant difference between the corresponding indexes in different time periods of the same group （P 〈 0.05）. There was no significant difference in the negative conversion rate between the control group after 3 months, 6 months and 9 months （P 〉 0.05）. Conclusion The treatment of different first-line ART therapy has obvious efect, which is worth popularizing.

关 键 词：艾滋病 替诺福韦+拉米夫定+奈韦拉平 齐多夫定+拉米夫定+依非韦伦 抗病毒治疗 CD4^+淋巴细胞计数 转阴率 

分 类 号：R512[医药卫生—内科学]