基于超分子“印迹模板”的中药成药性及制剂修饰研究策略  

Druggability and preparation modification of Chinese materia medica based on supramolecular “imprinted template”

作　　者：周晋[1,2,3] 刘惠 肖美凤[1,2,3] 杨岩涛 刘文龙[1,2,3] 邓凯文 贺福元[1,2,3] ZHOU Jin;LIU Hui;XIAO Mei-feng;YANG Yan-tao;LIU Wen-long;DENG Kai-wen;HE Fu-yuan(College of Pharmacy,Hunan University of Chinese Medicine,Changsha 410208,China;Hunan Provincial Key Laboratory of Drugahility and Preparation Modification of TCM,Changsha 410208,China;Supramolecular Mechanism and Mathematic-Physics Chracterization for Chinese Materia Medica,Hunan University of Chinese Medicine,Changsha 410208,China;The First Hospital of Hunan University of Chinese Medicine,Changsha 410007,China)

机构地区：[1]湖南中医药大学药学院,湖南长沙410208 [2]中药成药性与制剂制备湖南省重点实验室,湖南长沙410208 [3]湖南中医药大学中医药超分子机理与数理特征化实验室,湖南长沙410208 [4]湖南中医药大学第一附属医院,湖南长沙410007

出　　处：《中草药》2018年第18期4205-4211,共7页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(81573691;81703824;81874507;81803729;81874344);湖南省自然科学基金资助项目(2017JJ3236;2016JJ4065);湖南省教育厅基金(17B200);湖南省药学重点学科资助项目;中药成药性与制剂制备湖南省重点实验室开放基金(201708;201705);2011协同创新中心资助项目;国家留学基金资助项目

摘　　要：中药为多成分体系,除了重视单成分成药性研究外,其重点应放在如何整合单成分成药性规律,构建适宜中药多成分的成药性研究体系。中药基于中医药基础理论指导,其成药性已由长期的临床实践经验积累完成,疗效确定;目前最关键问题在于怎样对疗效明确的中药成分群进行归属并确定分子间相互作用规律,开发出组分中药。然而,怎样在单成分特性理化与生物性质基础上,整合形成多成分的表观理化与生物性质是中药成药性与制剂制备研究的关键。因此,中药的成药性研究既要完成单成分成药性的研究,还要利用中药配伍原理和现代超分子化学理论,研究中药多成分"分子社会"经配伍后其成药性变化规律,并与制剂、化学修饰结合起来,才能最大限度地提高中药新药创制的成功率。中药超分子"印迹模板"的自主"气析"作用规律对中药成药性研究具有重要的理论和实践指导作用。Chinese materia medica（CMM） is a multi-component system. In addition to the study on single-component druggability, the focus should be also on how to integrate the rules of single-component druggability to construct a research system of suitable multi-component druggability of CMM. According to the basic theory of CMM guidance, the druggability of CMM has been accumulated by long-term clinical practice experience, and the curative effect is affirmed. The most critical issue is how to determine the attribution and intermolecular interaction of the well-defined CMM component group and develop a component CMM. However, how to integrate the physicochemical and biological apparent properties of the multi-component based on the apparent physical and chemical properties of the single-component is the key to the study on druggability and preparation modification of CMM. Therefore, the druggability study of the single-component medicine and the study of the change rules of multi-component CMM druggability by using compatibility principle of CMM and modern supramolecular chemistry theory are needed to performed to study on the druggability of CMM. The combination of CMM druggability, preparations and chemical modifications can maximize the success rate of the development of new CMMs. The characteristic of the autonomous ＂Qi-xi＂ for CMM ＂imprinting template＂ of supramolecules has an important guiding role in druggability research of CMM both in theory and practice.

关 键 词：超分子 印迹模板 中药成药性 制剂修饰 二次开发 整合 

分 类 号：R283.3[医药卫生—中药学]