导电聚合物聚羟甲基EDOT抗免疫细胞粘附、增殖及活化性能研究  

Depressed Attachment,Proliferation and Activation of Immune Cells on Poly(hydroxymethyl EDOT)

作　　者：张述华 潘齐超 张亚琼[1] 钱思昊 朱波[1,2] ZHANG Shuhua;PAN Qichao;ZHANG Yaqiong;QIAN Sihao;ZHU Bo(State Key Lab for Modification of Chemical Fibers and Polymer Materials ＆ College of Materials Science and Engineering,Donghua University,Shanghai 201620,China;College of Materials Science and Engineering,Shanghai University,Shanghai 200444,China)

机构地区：[1]东华大学材料科学与工程学院纤维材料改性国家重点实验室,上海201620 [2]上海大学材料科学与工程学院,上海200444

出　　处：《材料开发与应用》2018年第4期24-34,共11页Development and Application of Materials

基　　金：上海市自然科学基金项目(14ZR1400200)

摘　　要：聚羟甲基EDOT(PEDOT-OH)具有良好的电化学性能,能进行多样化学改性,是一种优秀的有机电极材料。使用小鼠成纤维细胞(NIH 3T3)评价PEDOT-OH的生物相容性,然后以大鼠永生化小神经胶质细胞(HAPI)和大鼠原代巨噬细胞(RM)为免疫细胞模型,研究PEDOT-OH对HAPI细胞和RM细胞的粘附、增殖和活化的影响。结果表明,与聚苯乙烯(细胞培养孔板材料)相比,PEDOT-OH具有更好的生物相容性,对HAPI细胞和RM细胞的粘附、增殖和活化具有显著的抑制作用。Poly（ hydroxymethyl EDOT）（ PEDOT-OH） has been widely used as an electrode material for bioelectronics due to its excellent electrochemical performance and easy accessibility to chemical modification. In this work,the biocompatibility of PEDOT-OH by culturing NIH3T3 cells on it was evaluated. Effects of PEDOT-OH on the depressed attachment,proliferation and activation of two immune cells,the immortalized rat microglial cells（ HAPI） and rat primary macrophage（ RM）,were investigated. The results indicate that compared with polystgrene,PEDOT-OH has depressed significantly the attachment,proliferation and activation of HAPI cells and RM cells.

关 键 词：羟甲基EDOT 导电聚合物 生物相容性 小神经胶质细胞 巨噬细胞 

分 类 号：TQ317[化学工程—高聚物工业]