多囊卵巢综合征患者妊娠期内分泌激素异常对子代生长发育及相关激素水平的影响  

Influence of hormone abnormalities during pregnancy in women with PCOS on the growth and development of progeny and related hormones levels

作　　者：梁洁[1] 李艳娟[1] 刘梅[1] Liang Jie;Li Yanjuan;Liu Mei(Department of Obstetrics and Gynecology,The First People＇s Hospital of Qinzhou,Qinzhou 535001,China)

机构地区：[1]广西钦州市第一人民医院妇产科,钦州535001

出　　处：《广西医科大学学报》2018年第10期1372-1375,共4页Journal of Guangxi Medical University

摘　　要：目的:探讨多囊卵巢综合征(PCOS)患者妊娠期内分泌激素异常对子代生长发育及相关激素水平的影响。方法:选择2014年5月至2017年5月广西钦州市第一人民医院收治的90例PCOS孕妇作为观察组,以90例健康孕妇作为对照组。检测两组孕早、中、晚期外周静脉血及胎儿娩出后脐带血中游离甲状腺激素(FT4)、促甲状腺素(TSH)、促肾上腺皮质激素(ACTH)、皮质醇(COR)及睾酮(T)水平。测量去除脐带后的胎盘重量以及新生儿身高、体重。结果:两组孕妇孕早、中、晚期FT4水平比较,差异无统计学意义(P>0.05)。两组孕中、晚期ACTH水平均较孕早期明显下降(P<0.05),但观察组各时间点ACTH水平均明显高于对照组(P<0.05)。两组孕中、晚期COR、TSH水平均较孕早期明显上升(P<0.05),且观察组各时间点COR、TSH水平明显高于对照组;观察组孕早期、中期T水平低于对照组,而在孕晚期高于对照组(P<0.05)。观察组胎儿FT4、T水平均明显低于对照组,TSH、ACTH、COR水平明显高于对照组(P<0.05)。观察组胎盘重量和新生儿体重均明显低于对照组(P<0.05)。两组新生儿身高比较,差异无统计学意义(P>0.05)。结论:PCOS患者妊娠期内分泌激素异常可导致胎儿FT4、T水平下降,TSH、ACTH、COR水平升高,胎盘重量和新生儿体重降低。Objective：To investigate the influence of hormone abnormalities during pregnancy in women with polycystic ovarian syndrome（PCOS）on the growth and development of progeny and related hormones levels.Methods：A total of 90 pregnant women with PCOS（observation group）and 90 healthy pregnant women（control group）admitted to our hospital from May 2014 to May 2017 were selected.The free thyroid hormone（FT4）,thyrotropin（TSH）,adrenocorticotropic hormone（ACTH）,cortisol（COR）and testosterone（T）levels in blood were detected during early,mid and late pregnancy.After delivery,the FT4,TSH,ACTH,COR and T concentrations in umbilical cord blood as well as the placental weight and the height and weight of newborn infants were measured.Results：There was no significant difference in FT4 level during early,mid and late pregnancy between the two groups（P〉0.05）.The ACTH level was significantly lower in mid and late pregnancy than that in early pregnancy in both groups,while the COR,TSH and T levels was higher（P〈0.05）.Patients in the observation group had markedly higher levels of ACTH,COR and TSH,and lower T level than controls at any time point（P〈0.05）.Compared with the control group,the FT4 and T levels in cord blood were significantly decreased,whereas the TSH,ACTH,and COR levels were increased in the observation group（P〈0.05）.The placental weight and the weight of newborn infants in the observation group were notably lower than those in the control group（P〈0.05）.No significant difference was found in the height of newborns between the two groups（P〉0.05）.Conclusion：Hormone abnormalities during pregnancy in women with PCOS could lead to reduced FT4 and T levels,and elevated TSH,ACTH and COR levels in newborn infants,and it also caused placental weight and neonatal weight loss.

关 键 词：PCOS 妊娠期 内分泌异常 生长发育 

分 类 号：R445.1[医药卫生—影像医学与核医学] R711.75[医药卫生—诊断学]