IL-17在鼻病毒感染后哮喘中的作用机制研究进展  

Mechanism of IL-17 in asthmatic attacks after rhinovirus infection

作　　者：冀红[1] 吴泰华[2] JI Hong;WU Taihua(Pediatric Department,the First Affiliated Hospital of Dalian Medical University,Dalian 116011,China;Respiratory Department,the First Affiliated Hospital of Dalian Medical University,Dalian 116011,China)

机构地区：[1]大连医科大学附属第一医院儿科,辽宁大连116011 [2]大连医科大学附属第一医院呼吸内科,辽宁大连116011

出　　处：《大连医科大学学报》2018年第5期458-461,共4页Journal of Dalian Medical University

基　　金：辽宁省科技厅科学技术计划项目(2013225002)

摘　　要：儿童时期,呼吸道病毒感染是哮喘急性加重的重要原因,其中鼻病毒占2/3,而鼻病毒导致哮喘急性发作的机制尚不明确。本文从白介素-17与中性粒细胞炎症反应和气道重塑方面综述白介素-17在鼻病毒感染后哮喘中的作用机制,IL-17可以通过NF-κB,MARP以及T2-ERK1/2-MSK1信号转导通路发挥生物学作用。IL-17A和IL-17RA的单克隆抗体治疗Th17相关炎症的临床研究已有报道,这为治疗鼻病毒感染后哮喘提供了新的思路。In childhood, respiratory virus infection is an important cause of asthma. Rhinovirus accounted for about 2/3. The mechanism of wheezing caused by rhinovirus is still unclear. This article reviewed the role of IL-17 in asthmatic attacks after rhinovirus infection in airway inflammation and in airway remodeling. We also summarized the clinical trials of IL-17A and IL-17RA monoclonal antibodies in the treatment of IL17-related inflammation in order to provide new ideas for the treatment of asthmatic attcks after rhinovirus infection.

关 键 词：鼻病毒 哮喘 儿童 白介素-17 

分 类 号：R725.6[医药卫生—儿科]