T2 mapping MRI评估甲状腺相关性眼病免疫抑制疗效的初步研究  

T2 mapping MRI study on immunosuppression therapy of thyroid associated ophthalmopathy

作　　者：姜虹[1] 燕飞[1] 鲜军舫[1] 艾立坤[2] 王雪[3] JIANG Hong;YAN Fei;XIAN Jun-fan;AI Li-kun;WANG Xue(Department of Radiology;Department of Ophthalmology;Department of Endocrinology,Beijing Tongren Hospital,Capital Medical University,Beijing 100730,China)

机构地区：[1]首都医科大学附属北京同仁医院,放射科,100730 [2]首都医科大学附属北京同仁医院,眼科,100730 [3]首都医科大学附属北京同仁医院,内分泌科,100730

出　　处：《眼科》2018年第5期339-343,共5页Ophthalmology in China

摘　　要：目的探讨T_2 mapping MRI评估甲状腺相关性眼病(TAO)免疫抑制疗效的价值。设计前瞻性病例系列。研究对象74例经免疫抑制治疗的TAO患者。方法全部患者行冠状面T_2 mapping MRI成像,对图像进行分析。根据患者主要症状、体征及眼外肌功能的改善情况,将免疫抑制治疗效果分为有效和无效,有效分为极好、很好、一般,无效分为无变化、恶化。主要指标双侧各条眼外肌的T_2值,不同疗效患者治疗前maxT_2值及治疗前后maxT_2变化值。结果免疫抑制疗效极好者18例,很好者13例,一般者11例,无变化者30例,恶化者2例。有效组治疗前maxT_2显著大于无效组(P<0.001),治疗后maxT_2显著降低(P<0.001),且治疗效果越好,maxT_2变化值越大。治疗前maxT_2与治疗后maxT_2变化值呈显著线性负相关(r=0.643,P<0.0001)。结论眼外肌T_2 mapping MRI有助于评估TAO免疫抑制疗效。Objective To evaluate the value of T2 mapping MRI in evaluating immunosuppression therapy of thyroid associated ophthalmopathy （TAO）. Design Prospective case series. Participants 74 TAO patients with immunosuppression therapy. Method Coro- nal T2 mapping MRI was performed. According to the changes of main symptoms, sign and extraocular muscles （EOMs） function, the outcomes of immunosuppression therapy were divided into effectiveness and non-effectiveness. Effectiveness included excellent, well and general cases. Non-effectiveness included unchanged and deterioration cases. Main Outcome Measures T2 values of EOMs and the maxT2 changes. Results The treatment effect was excellent, well, general, unchanged and deteriorated in 18, 13, 11, 30 and 2 cases re- spectively. The maxT2 was significantly higher in effective group than in non-effective group （P〈O.001）. MaxT2 value decreased signifi- cantly after treatment （P〈0.001）. Correlation analysis revealed negative correlation between maxT2 and changes of maxT2 after thera- py （r=0.643, P〈0.0001）. Conclusions T2 mapping MRI is valuable in evaluation of TAO immunosuppression therapy effect.

关 键 词：甲状腺相关性眼病 T2mapping磁共振成像 免疫抑制治疗 

分 类 号：R581[医药卫生—内分泌] R771.3[医药卫生—内科学]