米非司酮治疗复发性围绝经期功血的临床观察  

Clinical Observation of Mifepristone in Treatment of Recurrent Perimenopausal Dysfunctional Uterine Bleeding

作　　者：丁仁波[1] Ding Renbo(Women ＆ Infants Hospital of Zhengzhou,Zhengzhou 450000,China)

机构地区：[1]郑州市妇幼保健院,郑州450000

出　　处：《成都医学院学报》2018年第5期609-611,共3页Journal of Chengdu Medical College

摘　　要：目的探讨应用米非司酮治疗围绝经期功血的临床效果。方法选取郑州市妇幼保健院门诊收治的围绝经期功血患者80例作为研究对象,随机将其分为对照组(妈富隆治疗)、试验组(米非司酮治疗),每组40例。观察两组患者治疗效果、复发率和激素水平变化及不良反应情况。结果试验组患者30例显效,8例有效,治疗总有效率为95%(38/40),对照组患者20例显效,11例有效,治疗总有效率为77.5%(31/40);两组总有效率比较,差异有统计学意义(P<0.05);观察组复发率7.5%(3/40),对照组复发率25.0%(10/40),两组患者复发率比较差异有统计学意义(P<0.05)。用药后实验组患者FSH、LH、E2激素水平均明显低于治疗前,差异有统计学意义(P<0.05),对照组患者E2激素水平明显低于治疗前,差异有统计学意义(P<0.05),两组患者用药期间不良反应发生率差异无统计学意义(P>0.05)。结论应用米非司酮治疗复发性围绝经期功血患者,能有效改善出血症状,降低复发率。Objective To investigate the clinical efficacy of mifepristone in treatment of perimenopausal dysfunctional uterine bleeding. Methods 80 cases with perimenopausal dysfunctional uterine bleeding treated in Women ＆ Infants Hospital of Zhengzhou were selected and divided randomly into the control group （treated with Marvelon） and the experiment group （treated with mifepristone）, and each group included 40 cases. The clinical efficacy, recurrence rate, changes of hormone levels and adverse reactions were observed in the two groups. Results In the experiment group, the treatment was markedly effective in 30 cases and effective in 8 cases, and the total effective rate was 95% （38/40）. In the control group, the treatment was markedly effective in 20 cases and effective in 11 cases, and the total effective rate was 77.5% （31/40）. The total effective rates were significantly different between the two groups （ P 〈0.05）. The recurrence rates were 7.5% （3/40） in the experiment group and 25.0% （10/40） in the control group, and the difference between the two groups was statistically significant （ P 〈0.05）. The hormone levels of FSH, LH and E 2 in the experiment group were significantly lower after treatment than before treatment （ P 〈0.05）, and the hormone level of E 2 in the control group was significantly lower after treatment than before treatment （ P 〈0.05）. There were no significant differences in the incidence of adverse reactions between the two groups during medication （ P 〉0.05）. Conclusion Mifepristone can effectively improve the bleeding symptoms and reduce the recurrence rate in the treatment of recurrent perimenopausal dysfunctional uterine bleeding.

关 键 词：围绝经期 功能性子宫出血 米非司酮 复发 

分 类 号：R711.52[医药卫生—妇产科学]