蜂针治疗变应性鼻炎的临床疗效和作用机理研究  

Research on Clinical Efficacy and Action Mechanism of Treatment for Allergic Rhinitis with Bee-sting Therapy

作　　者：赖耀铭[1] 李星儿[1] 吴红波[1] 高升[1] LAI Yao-ming;LI Xing-er;WU Hong-bo;GAO Sheng(Department of rehabilitation medicine,the Fifth Affiliated Hospital of Cuangzhou Medical University,Guangzhou,Guangdong,510700)

机构地区：[1]广州医科大学附属第五医院,广东广州510700

出　　处：《广西中医药大学学报》2018年第3期1-5,共5页Journal of Guangxi University Of Chinese Medicine

基　　金：广州市黄埔区科技计划项目(编号:201614);广州市卫生和计划生育科技项目(编号:20182A010023)

摘　　要：[目的]观察蜂针治疗过敏性鼻炎的临床效果及对患者血清特异性IgE水平、免疫学指标、生活质量等的影响,探讨蜂针治疗过敏性鼻炎的作用机理。[方法]将符合纳入标准的过敏性鼻炎患者90例作为研究对象,随机分为蜂针组、针刺组、西药组,每组30例。蜂针组以中华蜜蜂蛰刺患者风池、足三里、肺俞,每周治疗2次;针刺组以针刺治疗,以鼻三针(迎香、上迎香、印堂)为主穴,合谷、足三里为配穴,每周治疗2次;西药组以糠酸莫米松鼻喷雾剂喷鼻,三组疗程均为18周。[结果]总有效率蜂针组为100%,针刺组为86.7%,西药组为73.3%,蜂针组疗效优于其他两组(P<0.05)。蜂针组干预10周后、干预18周后、疗程结束后6周随访血清特异性IgE水平均显著低于其他两组(P<0.05)。蜂针组干预10周后、干预18周后、疗程结束6周后随访INF-γ、INF-γ/IL-4水平均显著高于其他两组(P<0.05),IL-4水平均显著低于其他两组(P<0.05)。蜂针治疗组干预10周后、干预18周后、疗程结束6周后随访SF-36评分均显著高于其他两组(P<0.05)。[结论]蜂针治疗过敏性鼻炎,能够有效改善患者血清特异性IgE水平、免疫学指标,提高生活质量,具有较高的临床应用价值。[Objective]To observe the clinical effect and influence of bee-sting therapy on allergic rhinitis and serum specific IgE level, immunological index as well as quality of life in patients so as to explore the action mechanism of bee-sting therapy in treating allergic rhinitis.[Methods]Ninety patients with allergic rhinitis who met the inclusion criteria were randomly divided into bee-sting therapy group, acupuncture group and western medicine group with 30 eases in each group. The bee-sting therapy group was treated with the Chinese honeybee stinging Fengehi, Zusanli and Feishu twice a week. The acupuncture group received acupuncture treatment with nasal three-needle （Yingxiang,Shangyingxiang, Yingtang） as the main points and Hegu as well as Zusanli as the matching points twice a week. The western medicine group was treated with nasal spray of mometasone furoate. The courses of treatment for three groups lasted 18 weeks. [Results]The total effective rate was 100% in bee-sting therapy group, 86.7% in acupuncture group and 73.33% in western medicine group. The therapeutic effect of bee-sting therapy group was better than that of the other two groups（P〈0.05 ）. The serum-specific IgE level in bee-sting therapy group was significantly lower than that in the other two groups at follow-up of 10 weeks and 18 weeks after intervention, and 6 weeks after the end of the treatment （P〈0.05）. The levels of INF-γ and INF-γ/ IL-4 in bee-sting therapy group were significantly higher than that in the other two groups（P〈0.05） and the IL-4 level in bee-sting therapy group was significantly lower than that in the other two groups at follow-up of 10 weeks and 18 weeks after intervention, and 6 weeks after the end of the treatment （P〈0.05）. The SF-36 score was significantly higher than that in the other two groups at follow-up of 10 weeks and 18 weeks after intervention, and 6 weeks after the end of the treatment （P〈0.05）. [ Conclusion]The treatment of bee-sting therapy on patients with allergic rhinit

关 键 词：过敏性鼻炎 蜂针 临床效果 免疫学指标 机理 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]