P物质在阻塞性睡眠呼吸暂停低通气综合征疾病中的调控作用  

Role of substance P in the regulation of obstructive sleep apnea hypopnea syndrome

作　　者：刘文敏 朱静静 刘华 Liu Wenmin;Zhu Jingling;Liu Hua(Department of Otolaryngology,Tangshan Gongren Hospital,Tangshan 063000,Chin;North China University of Science and Technology,Tangshan 063000,China)

机构地区：[1]唐山市工人医院耳鼻咽喉科,063000 [2]华北理工大学,唐山063000

出　　处：《国际耳鼻咽喉头颈外科杂志》2018年第5期280-283,共4页International Journal of Otolaryngology-Head and Neck Surgery

摘　　要：P物质是一种十一氨基酸多肽，广泛地分布于神经系统和其他外周组织器官内，其G蛋白偶联受体神经激肽1受体密集分布于舌下神经腹侧及背侧部。P物质不仅是一种神经肽，也是一种免疫调节因子，介导神经源性炎症、诱导多种炎症介质产生，介导白细胞肺浸润，参与呼吸道炎症性疾病的病理过程。阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者软腭、悬雍垂及舌根黏膜由于神经损伤，炎性前肽的增加导致神经源性炎症的病理变化，造成咽部气道容积减小甚至闭塞，从而导致OSAHS患者吸气时上气道阻力增加。而上气道肌肉由于失神经支配的损害，在上气道发生阻塞时会出现神经肌肉代偿不足。这些变化可能在OSAHS的发病机制中起一定作用。现就P物质及其受体与OSAHS的关系做一综述。Substance P is a eleven amino acid polypeptide, are widely distributed in the nervous system and other peripheral organs and tissues, the G protein coupled receptor neurokinin 1 receptor distributed in the ventral and dorsal nerve of tongue. Substance P is not only a neuropeptide, but also an immunomodulatory factor, mediating neurogenic inflammation, inducing a variety of inflammatory mediators, mediating leukocyte infiltration and participating in the pathological process of respiratory inflammatory diseases. Obstructive sleep apnea syndrome in patients with soft palate, uvula and tongue mucosa due to nerve damage hypopnea syndrome, inflammatory propeptide leads to the increase of pathological changes of neurogenic inflammation, resulting in pharyngeal airway volume decrease or occlusion, leading to increased inspiratory airway resistance in patients with OSAHS when. When the upper airway muscles are innervated by the denervation, there will be a lack of neuromuscular compensation when the upper airway is blocked. These changes may play a role in the pathogenesis of OSAHS. This review is a review of the relationship between substance P and its receptors and obstructive sleep apnea hypopnea syndrome.

关 键 词：P物质 神经肽类 睡眠呼吸暂停 阻塞性 舌下神经 

分 类 号：R766[医药卫生—耳鼻咽喉科]