HPLC手性流动相添加剂及其用于药物对映体拆分中的影响因素  

HPLC Chiral Mobile Phase Additive and the Influencing Factors of using it to the Resolution of Drug Enantiomers

作　　者：徐雄[1] 宁卫红 瞿志荣[2] 杨瑞卿[1] 谢永荣[1] Xu Xiong;Ning Wei-hong;Qu Zhi-rong;Yang Rui-qing;Xie Yong-rong(Key Laboratory of Jiangxi University for Functional Materials Chemistry,College of Chemistry and Chemical Engineering,Gannan Normal University,Jiangxi Ganzhou 341000;Laboratory of Organosilieon Chemistry and Material,Hangzhou Normal University,Zhejiang Hangzhou 311121)

机构地区：[1]赣南师范大学化学化工学院,江西省高校功能材料化学重点实验室,江西赣州341000 [2]杭州师范大学有机硅化学及材料实验室,浙江杭州311121

出　　处：《生物化工》2018年第5期150-155,共6页Biological Chemical Engineering

基　　金：国家自然科学基金(21461002、20861001);江西省高等学校功能材料化学重点实验室开放课题(FMC15103);研究生创新专项资金项目(YCX17B003)

摘　　要：高效液相色谱手性流动相添加剂法是拆分药物对映体的方法之一。它不需要使用手性柱也能高效分离药物对映体,且具有操作简便、应用范围广和通用性好等特点。本文综述了手性流动相添加剂的种类,其拆分药物对映体的原理及在拆分过程中的影响因素,对药物对映体的拆分具有重要指导意义。The chiral mobile phase additives method in High performance liquid chromatography （HPLC） is one of the methods of resolving drug enantiomers. This method does not require the use of chiral column, can efficiently separate the drug enantiomers, and has the advantages of simple operation, wide application and universality. This paper summarizes the types of chiral mobile phase additives, the principle of using it to the resolution of drug enantiomers and their influencing factors in the application of resolution, which are of great significance to the resolution of the drug enantiomers.

关 键 词：高效液相色谱 流动相 手性添加剂 对映体拆分 

分 类 号：O657.72[理学—分析化学]