妊娠期糖尿病患者炎症因子、氧化应激水平及其与胰岛素抵抗的关系  

The relationship between inflammatory factors,oxidative stress of pregnant women with gestational diabetes mellitus and their insulin resistance

作　　者：蒋惠玲[1] 薛筱蕾 阿米娜[1] JIANG Huiling;XUE Xiaolei;Amina(The Fifth Hospital Affiliated to Xinjiang Medical University,Urumqi,Xinjiang,830011)

机构地区：[1]新疆医科大学第五附属医院,乌鲁木齐830011

出　　处：《中国计划生育学杂志》2018年第10期965-967,971,共4页Chinese Journal of Family Planning

摘　　要：目的:探讨妊娠期糖尿病患者炎症因子、氧化应激水平及其与胰岛素抵抗的关系。方法:选取2017年1月—2017年12月本院确诊为妊娠期糖尿病的患者66例作为观察组,同期正常妊娠女性60例作为对照组,检测空腹血糖(FBG)、胰岛素(FINS)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)、丙二醛(MDA)、超氧化物歧化酶(SOD)、谷胱甘肽(GSH)以及总抗氧化能力(TAOC),计算胰岛素抵抗指数(HOMA-IR)。结果:观察组的FBG、FINS、HOMA-IR、IL-6、TNF-α、hs-CRP、MDA水平均高于对照组,SOD、GSH、TAOC水平均低于对照组(均P<0.05)。观察组IL-6、TNF-α、hs-CRP、MDA水平与HOMA-IR呈显著正相关(P<0.05),SOD、GSH、TAOC水平与HOMA-IR呈显著负相关(P<0.05)。结论:妊娠期糖尿病患者炎症因子、氧化应激水平与胰岛素抵抗紧密相关。Objective： To explore the relationship between inflammatory factors, oxidative stress of pregnant women with gestational diabetes mellitus （GDM） and their insulin resistance. Methods： From January 2017 to December 2017, 66 pregnant women with GDM in the fifth hospital affiliated to Xinjiang medical university were selected into observation group, and 60 normal pregnant women during the same period were selected into control group. All included women were detected their fasting blood glucose （FBG）, fasting insulin （FINS）, interleukin 6 （IL 6）, tumor necrosis factor alpha （TNF α）, high sensitivity C reactive protein （hs CRP）, and C Dialdehyde （MDA）, superoxide dismutase （SOD）, glutathione （GSH） and total antioxidant capacity （TAOC）. And insulin resistance index （HOMA IR） of all women was calculated. Results： The levels of FBG, FINS, HOMA IR IL 6, TNF α and hs CRP, and MDA of women in observation group were significant higher than those of women in control group （ P 〈0.05）, but the levels of SOD, GSH, and TAOC of women in observation group were significant lower than those of women in control group （ P 〈0.05）.In observation group, there was positive correlation between level of IL 6, TNF α, hs CRP or MDA and HOMA IR （ P 〈0.05）, but there was negative correlation between HOMA IR and level of SOD, GSH, or TAOC （ P 〈0.05）. Conclusion： The levels of inflammatory factors and oxidative stress of pregnant women with GDM are closely related to their insulin resistance.

关 键 词：妊娠期糖尿病 炎症因子 氧化应激 胰岛素抵抗 

分 类 号：R714.256[医药卫生—妇产科学]