轻度颅脑外伤患者尿液中阿尔茨海默病相关神经丝蛋白(AD7c-NTP)变化的研究  

The study of urine AD7c-NTP in patients with mild brain injury

作　　者：汤朱骁 刘伟贤[1] 石晓勇[1] 龚杰[1] 沈峥[1] TANG Zhuxiao;LIU Weixian;SHI Xiaoyong(Zhejiang Hospital,Zhejiang 310013,China)

机构地区：[1]浙江医院,杭州310013

出　　处：《浙江创伤外科》2018年第5期851-853,共3页Zhejiang Journal of Traumatic Surgery

摘　　要：目的探讨轻度颅脑外伤患者尿液中阿尔茨海默病相关神经丝蛋白(AD7c-NTP)的变化。方法收集本院收治的轻度颅脑外伤患者75例、阿尔兹海默病(AD)患者69例及体检中心体检正常的人员70例的临床资料,并观察比较3个月观察期的尿AD7c-NTP含量变化。结果轻度颅脑外伤患者尿AD7c-NTP明显高于正常人,且与AD患者相近,差异性具有统计学意义(P<0.05)。结论轻度颅脑外伤患者存在神经元的损害,其尿AD7c-NTP水平的变化,提示轻度颅脑外伤会提高病人得AD的几率。Objective To investigate the changes of Alzheimer-associated neuronal thread protein （AD7c-NTP）in urine of patients with mildbrain injury. Methods Collecting the clinical data of 75 patients with mild brain injury, 69 patients with Alzheimer＇s disease, and 70 people withnormal physical examination from medical examination center of our hospital, to observe the changes of AD7c-NTP in urine for3 months. ResultsThe urine AD7c-NTP in patients with mild craniocerebral injury was similar to AD patients, and significantly higher than that in normal people, thedifference was statistically significant（P〈0.05）. Conclusion Patients with mild traumatic brain injury maybe exist neuronal damage, because thechanges of AD7c-NTP in the urine of the patients, which suggest that mild traumatic brain injury may increase the opportunity of getting AD.

关 键 词：阿尔茨海默病相关神经丝蛋白 轻度颅脑外伤 尿液 

分 类 号：R651.1[医药卫生—外科学]