正交设计优选化瘀散凝胶贴膏基质配方  

Study on Optimizing Matrix Formulation of Huayusan Gel Patch by Orthogonal Design

作　　者：黄雍[1,2] 文敏 杨磊[1,2] 戴冰[1] 李玉星 HUANG Yong;WEN Min;YANG Lei;DAI Bing;LI Yuxing(The First Hospital of Hunan University of Chinese Medicine,Changsha 410007,China;Zhang Zhiguo National Heritage of Traditional Chinese Medicine Expert Studio,Changsha 410007,China;Hunan University of Chinese Medicine,Changsha 410013,China)

机构地区：[1]湖南中医药大学第一附属医院,长沙410007 [2]全国名老中医药专家张志国传承工作室,长沙410007 [3]湖南中医药大学,长沙410013

出　　处：《中国现代应用药学》2018年第9期1299-1302,共4页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的优选化瘀散凝胶贴膏基质配方制备工艺的最佳条件。方法采用正交设计试验,以凝胶贴膏的初黏力、持黏力、剥离强度及追随性为考察指标,对聚丙烯酸钠、明胶、甘油和丙二醇的用量进行优选,确定基质中不同辅料的最佳配比。结果优选出化瘀散凝胶贴膏最佳基质处方配比为聚丙烯酸钠∶明胶∶甘油∶丙二醇=4∶3∶3∶2。结论以最优处方基质配比制备的凝胶贴膏,表面平整光滑,具有良好的黏附性和保湿性。OBJECTIVE To optimize preparation technology of matrix formulation of Huayusan gel patch. METHODS The orthogonal experiment was used to adjust the dosage of sodium polyacrylate, gelatin, glycerinum and propylene glycol and determine optimized proportion of different excipients in matrix with temperciance, permanent adhesion, peel strength, tracing ability of gel patch as the indexes. RESULTS The optimized proportion of matrix formulation in Huayusan gel patch was sodium polyacrylate∶gelatin∶glycerinum∶propylene glycol = 4∶3∶3∶2. CONCLUSION The best composition of prescription of Huayusan gel patch is selected. The gel patch made by this prescription is glossy smooth, with pretty good adhesive and humectant properties.

关 键 词：化瘀散 凝胶贴膏 正交设计法 

分 类 号：R944[医药卫生—药剂学]