母婴血型不合新生儿溶血病早期干预治疗的疗效研究  

Effect of Early Intervention on Hemolytic Disease of Newborn with Maternal and Infant Blood Group Incompatibility

作　　者：杨锦明[1] YANG Jin-ming(The First People＇s Hospital of Akesu,Akesu,Xinjiang,84300)

机构地区：[1]新疆阿克苏地区第一人民医院,新疆阿克苏843000

出　　处：《智慧健康》2018年第14期39-41,共3页Smart Healthcare

摘　　要：目的探讨与分析母婴血型不合新生儿溶血病早期干预治疗的效果及临床应用价值。方法从本院2016年5月至2018年4月接收的新生儿溶血病患者中,随机抽取48例患者,采用奇偶排序法对所选患者进行排序,24例奇数患者作为观察组,接受蓝光照射、注射人血白蛋白联合大剂量注射人免疫球蛋白进行治疗,24例偶数患者作为对照组,接受蓝光照射联合注射人血白蛋白进行治疗。对比两组患者临床治疗效果,观察两组患者治疗前后血红蛋白(Hb)、血清总胆红素(TBIL)变化情况,观察两组患者黄疸消退时间、蓝光照射时间、住院时间等指标。结果 (1)两组患者治疗前Hb、TBIL水平无显著差异,比较结果无统计学意义(P>0.05);(2)观察组患者治疗总有效率显著高于对照组;(3)观察组患者治疗后Hb水平高于对照组,且TBIL水平低于对照组;(4)观察组患者黄疸消退时间、蓝光照射时间、住院时间均低于对照组;比较结果有统计学意义(P<0.05)。结论对新生儿溶血病患者采用大剂量注射免疫球蛋白治疗的方法能够极大的降低患者血清总胆红素的含量,阻止继续溶血情况的发生,并且有效的缓解了患者的黄疸症状,缩短了患者蓝光照射治疗的时间以及住院时间,促进了患者的恢复和预后,临床价值较高,值得推广使用。Objective To investigate and analyze the effect and clinical value of early intervention therapy for neonatal hemolytic disease in maternal and neonatal blood group. Methods From May 2016 to April 2018, 48 patients with hemolytic disease of the newborn were random Ly selected. The selected patients were sorted by odd-even method. 24 odd-numbered patients were used as observation group. Blue light irradiation and injection of human albumin combined with large dose injection of human immunoglobulin were used for treatment. 24 even-numbered patients were used as control group and received blue light irradiation combined with human serum albumin for treatment. The effect of clinical treatment was compared between the two groups of patients. The changes of hemoglobin（Hb） and serum total bilirubin（TBIL） before and after treatment were observed. The indicators such as the time of jaundice disappearing, the time of blue light irradiation, and the length of hospital stay were observed. Results（1） There was no significant difference in the levels of Hb and TBIL between the two groups before treatment. The comparison results were not statistically significant（P〈0.05）.（2） The total effective rate of treatment in the observation group was significantly higher than that in the control group;（3） The level of Hb in the observation group was higher than that in the control group after treatment, and the level of TBIL was lower than that in the control group;（4） The time of the jaundice disappeared, the time of the blue light irradiation, and the time of hospitalization were all observed in the observation group. Lower than the control group; the results were statistically significant（P〈0.05）. Conclusion The method of high-dose injection of immunoglobulin for neonatal hemolytic patients can greatly reduce the serum total bilirubin content, prevent the occurrence of continued hemolysis, and prognosis of the patients. The clinical value is high and it is worth promoting.

关 键 词：血型 新生儿溶血病 免疫球蛋白 蓝光照射 

分 类 号：R722.18[医药卫生—儿科]