153例药品不良反应发生的药品及表现原因分析  

Analysis of Drugs and Manifestation of 153 cases of Adverse Drug Reactions Occurred

作　　者：李荣[1] 李洁[1] 刘婷[1] 龚茜 柯刚[1] LI Rong;LI Jie;LIU Ting;GONG Qian;KE Gang(Luzhou People＇s Hospital,Luzhou,Sichuan,64600)

机构地区：[1]泸州市人民医院,四川泸州646000

出　　处：《智慧健康》2018年第20期28-29,共2页Smart Healthcare

摘　　要：目的统计和分析153例药品不良反应(ADR)发生情况,分析其发生特点及表现,预防和减少药品不良反应的发生。方法收集ADR报告,按药品种类、ADR累及系统及临床表现等进行统计分析。结果共涉及药品86种,其中,抗菌药物有66例,占43.14%;其中β内酰胺类最多占抗菌药物的60.61%。其次为氟喹诺酮类,占10.46%。中药注射剂共发生22例,占14.38%。其他类药物共发生65例,占42.48%。皮肤及附件损害共39例(25.49%)居首位。其主要临床表现为瘙痒、皮疹、潮红等;其次为白细胞、中性粒细胞、血小板减少等血液系统损伤,共23例,占15.03%;心血管系统损害共18例(11.76%)。结论医务工作者应重视ADR的监测,保障临床合理用药,减少ADR的发生。Objective To analyze 153 cases of adverse drug reactions（ADR）, analyze its features and performance, so as to prevent or reduce the occurrence of adverse drug reactions. Methods Collect ADR report, according to the types of drugs, and clinical manifestations of ADR involving system were analyzed. Results 86 kinds of drugs are involved, among them, the antibacterial drugs in 66 patients, accounted for 43.14%; The largest beta lactam type accounted for 60.61% of antimicrobial agents. Secondly it is fluoroquinolone accounted for 10.46%. Traditional Chinese medicine injections, a total of 22 cases, accounted for 14.38%. Other drugs 65 cases, accounted for 42.48%. Damage to the skin and accessories, a total of 39 cases（25.49%） in the first place. Its main clinical manifestation is itching、rashes、flush, etc.; Followed by white blood cells, neutrophil and platelet reduce blood system damage, a total of 23 cases, accounted for 15.03%; Cardiovascular system damage, a total of 18 cases（11.76%）. Conclusion Medical workers should pay attention to ADR monitoring, ensure the clinical rational drug use, reduce the occurrence of ADR.

关 键 词：不良反应 合理用药 抗菌药物 中药注射剂 

分 类 号：R95[医药卫生—药学]